Modulation of the Release of a Non-Interacting Low Solubility Drug from Chitosan Pellets Using Different Pellet Size, Composition and Numerical Optimization.

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作者： Ioannis,Partheniadis ^[1] ; Paraskevi,Gkogkou ^[2] ; Nikolaos,Kantiranis ^[3] ; Ioannis,Nikolakakis ^[4]

作者单位： Department of Pharmaceutical Technology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. ioanpart@pharm.auth.gr. ^[1] Department of Pharmaceutical Technology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. gkogkop@gmail.com. ^[2] Department of Mineralogy-Petrology-Economic Geology, School of Geology, Faculty of Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. kantira@geo.auth.gr. ^[3] Department of Pharmaceutical Technology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. yannikos@pharm.auth.gr. ^[4]

关键词 crystallinity 3 extended release 6 fast release 5 pellet diameter 2 pellets 1 sphericity 4

DOI 10.3390/pharmaceutics11040175

PMID 30974869

发布时间 2020-09-30

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