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Role of endoplasmic reticulum stress and protein misfolding in disorders of the liver and pancreas.

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第一作者： Jan,Lukas

第一单位： Albrecht-Kossel-Institute for Neuroregeneration, Rostock University Medical Centre, Rostock, Mecklenburg-Vorpommern, Germany.

作者： Jan,Lukas ^[1] ; Jola,Pospech ^[2] ; Christina,Oppermann ^[3] ; Christina,Hund ^[1] ; Katharina,Iwanov ^[1] ; Supansa,Pantoom ^[1] ; Janine,Petters ^[1] ; Moritz,Frech ^[1] ; Susanne,Seemann ^[1] ; Franziska-Gisela,Thiel ^[4] ; Jana-Marielle,Modenbach ^[4] ; Robert,Bolsmann ^[4] ; Laura,de Freitas Chama ^[4] ; Franziska,Kraatz ^[4] ; Firas,El-Hage ^[2] ; Manuel,Gronbach ^[3] ; Annelie,Klein ^[5] ; Regina,Müller ^[6] ; Sabine,Salloch ^[6] ; Frank-Ulrich,Weiss ^[4] ; Peter,Simon ^[4] ; Preshit,Wagh ^[4] ; Almuth,Klemenz ^[4] ; Elke,Krüger ^[7] ; Julia,Mayerle ^[8] ; Mihaela,Delcea ^[5] ; Udo,Kragl ^[3] ; Matthias,Beller ^[2] ; Arndt,Rolfs ^[1] ; Markus M,Lerch ^[4] ; Matthias,Sendler ^[9]

作者单位： Albrecht-Kossel-Institute for Neuroregeneration, Rostock University Medical Centre, Rostock, Mecklenburg-Vorpommern, Germany. ^[1] Leibniz-Institute for Catalysis at the University of Rostock, Rostock, Germany. ^[2] Department of Chemistry, University of Rostock, Rostock, Germany. ^[3] Department of Medicine A, University Medicine Greifswald, Greifswald, Germany. ^[4] ZIK HIKE Innovation Center, Humoral Immune Responses in Cardiovascular Disorders, University of Greifswald, Germany. ^[5] Institute of Ethics and History of Medicine, University Medicine Greifswald, Greifswald, Germany. ^[6] Department of Medical Biochemistry and Molecular Biology, University Medicine Greifswald, Greifswald, Germany. ^[7] Department of Medicine II, Ludwigs-Maximilians University Munich, Munich, Germany; Department of Medicine A, University Medicine Greifswald, Greifswald, Germany. ^[8] Department of Medicine A, University Medicine Greifswald, Greifswald, Germany. Electronic address: matthias.sendler@uni-greifswald.de. ^[9]

关键词 ER stress Endoplasmic reticulum associated protein degradation-ERAD Pancreatitis Unfolded protein response Wilson’s disease

医学主题词动物(Animals);人类(Humans);肝(Liver);胰腺(Pancreas);蛋白质折叠(Protein Folding);非折叠蛋白质应答(Unfolded Protein Response)

DOI 10.1016/j.advms.2019.03.004

PMID 30978662

发布时间 2020-04-13

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