HIF1A and NFAT5 coordinate Na<sup>+</sup>-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting.-论文-万方医学网

作者： Patrick,Neubert ^[1] ; Andrea,Weichselbaum ^[1] ; Carmen,Reitinger ^[1] ; Valentin,Schatz ^[1] ; Agnes,Schröder ^[2] ; John R,Ferdinand ^[3] ; Michaela,Simon ^[1] ; Anna-Lorena,Bär ^[1] ; Christoph,Brochhausen ^[4] ; Roman G,Gerlach ^[5] ; Stefan,Tomiuk ^[6] ; Karin,Hammer ^[7] ; Stefan,Wagner ^[7] ; Ger,van Zandbergen ^[8] ; Katrina J,Binger ^[9] ; Dominik N,Müller ^[10] ; Kento,Kitada ^[11] ; Menna R,Clatworthy ^[12] ; Christian,Kurts ^[3] ; Jens,Titze ^[13] ; Zeinab,Abdullah ^[12] ; Jonathan,Jantsch ^[13]

作者单位： Institute of Clinical Microbiology and Hygiene, University Hospital of Regensburg and University of Regensburg , Regensburg , Germany. ^[1] Institute of Orthodontics, University Hospital of Regensburg , Regensburg , Germany. ^[2] Molecular Immunity Unit, Department of Medicine, MRC-Laboratory of Molecular Biology, University of Cambridge , Cambridge , UK. ^[3] Institute of Pathology, University of Regensburg , Regensburg , Germany. ^[4] Project Group 5, Robert Koch Institute , Wernigerode , Germany. ^[5] Miltenyi Biotec GmbH , Bergisch Gladbach , Germany. ^[6] Department of Internal Medicine II, University Hospital of Regensburg and University of Regensburg , Regensburg , Germany. ^[7] Division of Immunology, Paul-Ehrlich-Institute , Langen , Germany. ^[8] Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne , Parkville , Australia. ^[9] Experimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin , Berlin , Germany. ^[10] Max-Delbrück Center for Molecular Medicine in the Helmholtz Association , Berlin , Germany. ^[11] Cardiovascular and Metabolic Disorders, Duke-NUS Medical School , Singapore. ^[12] Institute of Experimental Immunology, University of Bonn , Bonn , Germany. ^[13]

主题词动物(Animals);自噬(Autophagy);大肠杆菌(Escherichia coli);同源盒结构域蛋白质类(Homeodomain Proteins);氢离子浓度(Hydrogen-Ion Concentration);缺氧诱导因子1, α亚基(Hypoxia-Inducible Factor 1, alpha Subunit);炎症(Inflammation);溶酶体(Lysosomes);巨噬细胞(Macrophages);甘露醇(Mannitol);小鼠(Mice);显微镜检查, 电子, 透射(Microscopy, Electron, Transmission);一氧化氮合酶Ⅱ型(Nitric Oxide Synthase Type II);寡核苷酸序列分析(Oligonucleotide Array Sequence Analysis);渗透压(Osmotic Pressure);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);活性氧(Reactive Oxygen Species);钠(Sodium);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);转录因子(Transcription Factors)

DOI 10.1080/15548627.2019.1596483

PMID 30982460

发布时间 2024-03-20

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HIF1A and NFAT5 coordinate Na<sup>+</sup>-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting.

Autophagy

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Autophagy

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HIF1A and NFAT5 coordinate Na<sup>+</sup>-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting.

Autophagy

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Autophagy

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