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Modeling the Pathological Long-Range Regulatory Effects of Human Structural Variation with Patient-Specific hiPSCs.

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作者单位: Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; Institute of Human Genetics, CMMC, University Hospital Cologne, Cologne, Germany. [1] Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. [2] Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. [3] Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark. [4] Erasmus Medical Center, University of Rotterdam, Rotterdam, the Netherlands. [5] Center for Physiology and Pathophysiology, Institute for Neurophysiology, Medical Faculty, University of Cologne, Cologne, Germany. [6] Department of Pediatrics, University Clinic Carl Gustav Carus, TU Dresden, Dresden, Germany. [7] Human Genetics & Genomic Medicine, University of Southampton, Southampton General Hospital, Southampton, UK; Clinical Genetics Service, University Hospital Southampton NHS Foundation Trust, Princess Anne Hospital, Southampton, UK. [8] Molecular Genetics Department, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK. Electronic address: julia.baptista@nhs.net. [9] Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany; Institute of Biomedicine and Biotechnology of Cantabria (IBBTEC), University of Cantabria, Cantabria, Spain. Electronic address: aradaigl@uni-koeln.de. [10]
DOI 10.1016/j.stem.2019.03.004
PMID 30982769
发布时间 2020-07-16
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