Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction.

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作者： Sophia,von Stockum ^[1] ; Alvaro,Sanchez-Martinez ^[2] ; Samantha,Corrà ^[3] ; Joy,Chakraborty ^[4] ; Elena,Marchesan ^[3] ; Lisa,Locatello ^[1] ; Caterina,Da Rè ^[3] ; Paola,Cusumano ^[3] ; Federico,Caicci ^[4] ; Vanni,Ferrari ^[3] ; Rodolfo,Costa ^[4] ; Luigi,Bubacco ^[3] ; Maria Berica,Rasotto ^[3] ; Ildiko,Szabo ^[3] ; Alexander J,Whitworth ^[4] ; Luca,Scorrano ^[3] ; Elena,Ziviani ^[3]

作者单位： Fondazione Ospedale San Camillo, IRCCS, Venezia, Italy. ^[1] MRC Mitochondrial Biology Unit, Cambridge Biomedical Campus, Cambridge, UK. ^[2] Department of Biology, University of Padova, Padova, Italy. ^[3] Neurogenetics and Behavior of Drosophila Lab, Department of Biology, University of Padova, Padova, Italy. ^[4] Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, Padova, Italy. ^[5] Fondazione Ospedale San Camillo, IRCCS, Venezia, Italy elena.ziviani@unipd.it. ^[6]

主题词动物(Animals);细胞系(Cell Line);二甲亚砜(Dimethyl Sulfoxide);多巴胺(Dopamine);减量调节(Down-Regulation);果蝇属(Drosophila);果蝇蛋白质类(Drosophila Proteins);黑腹果蝇(Drosophila melanogaster);基因沉默(Gene Silencing);长寿(Longevity);男(雄)性(Male);膜蛋白质类(Membrane Proteins);线粒体(Mitochondria);帕金森病(Parkinson Disease);表型(Phenotype);信号传导(Signal Transduction);转染(Transfection);泛素蛋白连接酶类(Ubiquitin-Protein Ligases)

DOI 10.26508/lsa.201900392

PMID 30988163

发布时间 2023-02-01

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Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction.

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Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction.

Life science alliance

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