Discovery of trans-3-(pyridin-3-yl)acrylamide-derived sulfamides as potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitors for the potential treatment of cancer.

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作者： Kuojun,Zhang ^[1] ; Yong,Ni ^[2] ; Jiaxuan,Chen ^[3] ; Zhengchao,Tu ^[4] ; Xiaoxing,Wu ^[3] ; Dong,Chen ^[3] ; Hequan,Yao ^[3] ; Sheng,Jiang ^[5]

作者单位： Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; University of Chinese Academy of Sciences, Beijing 100049, China; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. ^[1] Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; University of Chinese Academy of Sciences, Beijing 100049, China. ^[2] State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. ^[3] Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China. ^[4] State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: jiangsh9@gmail.com. ^[5]

关键词 Acrylamide Anticancer Antiproliferative activity Biarylsulfanilamide NAMPT inhibitor

主题词细胞系, 肿瘤(Cell Line, Tumor);人类(Humans);模型, 分子(Models, Molecular);肿瘤(Neoplasms);烟酰胺磷酸核糖基转移酶(Nicotinamide Phosphoribosyltransferase);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.bmcl.2019.04.013

PMID 30992165

发布时间 2020-09-21

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