Screening of CRISPR/Cas base editors to target the AMD high-risk Y402H complement factor H variant.

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第一作者： Minh Thuan Nguyen,Tran

第一单位： Menzies Institute for Medical Research, University of Tasmania, Tasmania, Australia.

作者： Minh Thuan Nguyen,Tran ^[1] ; Mohd Khairul Nizam Mohd,Khalid ^[1] ; Alice,Pébay ^[2] ; Anthony L,Cook ^[3] ; Helena H,Liang ^[4] ; Raymond C B,Wong ^[5] ; Jamie E,Craig ^[2] ; Guei-Sheung,Liu ^[2] ; Sandy S,Hung ^[3] ; Alex W,Hewitt ^[6]

作者单位： Menzies Institute for Medical Research, University of Tasmania, Tasmania, Australia. ^[1] Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Victoria, Australia. ^[2] Ophthalmology, Department of Surgery, University of Melbourne, Victoria, Australia. ^[3] Department of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia. ^[4] Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, TAS 7000, Australia. ^[5] Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, Australia. ^[6]

主题词碱基序列(Base Sequence);补体因子H(Complement Factor H);胞嘧啶(Cytosine);基因表达(Gene Expression);HEK293细胞(HEK293 Cells);高通量核苷酸序列分析(High-Throughput Nucleotide Sequencing);人类(Humans);乳糖操纵子(Lac Operon);黄斑变性(Macular Degeneration);突变(Mutation);质粒(Plasmids);胸腺嘧啶(Thymine)

PMID 30996586

发布时间 2024-07-15

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Molecular vision

2019年25卷

174-182页

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Screening of CRISPR/Cas base editors to target the AMD high-risk Y402H complement factor H variant.

Molecular vision

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Screening of CRISPR/Cas base editors to target the AMD high-risk Y402H complement factor H variant.

Molecular vision

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Molecular vision

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