High-Fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett's Esophagus via Interleukin 8 and Alterations to the Gut Microbiome.-论文-万方医学网

作者： Natasha Stephens,Münch ^[1] ; Hsin-Yu,Fang ^[2] ; Jonas,Ingermann ^[1] ; H Carlo,Maurer ^[3] ; Akanksha,Anand ^[2] ; Victoria,Kellner ^[2] ; Vincenz,Sahm ^[2] ; Maria,Wiethaler ^[2] ; Theresa,Baumeister ^[2] ; Frederik,Wein ^[2] ; Henrik,Einwächter ^[2] ; Florian,Bolze ^[4] ; Martin,Klingenspor ^[4] ; Dirk,Haller ^[5] ; Maria,Kavanagh ^[6] ; Joanne,Lysaght ^[6] ; Richard,Friedman ^[7] ; Andrew J,Dannenberg ^[8] ; Michael,Pollak ^[9] ; Peter R,Holt ^[10] ; Sureshkumar,Muthupalani ^[11] ; James G,Fox ^[11] ; Mark T,Whary ^[11] ; Yoomi,Lee ^[7] ; Tony Y,Ren ^[7] ; Rachael,Elliot ^[12] ; Rebecca,Fitzgerald ^[13] ; Katja,Steiger ^[14] ; Roland M,Schmid ^[2] ; Timothy C,Wang ^[7] ; Michael,Quante ^[15]

作者单位： Department of Internal Medicine, Technical University of Munich, Germany; Chair of Molecular Nutritional Medicine, Technical University of Munich, Germany. ^[1] Department of Internal Medicine, Technical University of Munich, Germany. ^[2] Department of Internal Medicine, Technical University of Munich, Germany; Irvine Cancer Research Center, Columbia University, New York, New York. ^[3] Chair of Molecular Nutritional Medicine, Technical University of Munich, Germany; EKFZ-Else Kröner-Fresenius Center for Nutritional Medicine, Technical University of Munich, Germany; ZIEL-Institute of Food & Health, Technical University of Munich, Germany. ^[4] Technical University of Munich, Germany. ^[5] Department of Surgery, Trinity Translational Medicine Institute, Trinity College Dublin, Ireland. ^[6] Irvine Cancer Research Center, Columbia University, New York, New York. ^[7] Weill Cornell Medical College, New York, New York. ^[8] McGill University, Montreal, Quebec, Canada. ^[9] Rockefeller University, New York, New York. ^[10] Massachusetts Institute of Technology, Cambridge, Massachusetts. ^[11] University of California San Francisco, California. ^[12] Cambridge University, Cambridge, UK. ^[13] Institute of Pathology, Technical University of Munich, Germany. ^[14] Department of Internal Medicine, Technical University of Munich, Germany. Electronic address: michael.quante@tum.de. ^[15]

主题词腺癌(Adenocarcinoma);成年人(Adult);老年人(Aged);动物(Animals);Barrett食管(Barrett Esophagus);疾病模型, 动物(Disease Models, Animal);疾病恶化(Disease Progression);食管肿瘤(Esophageal Neoplasms);食管(Esophagus);粪便(Feces);女(雌)性(Female);人类(Humans);白细胞介素8(Interleukin-8);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 转基因(Mice, Transgenic);中年人(Middle Aged);肥胖症(Obesity);类器官(Organoids);血清(Serum);时间因素(Time Factors);组织培养技术(Tissue Culture Techniques)

DOI 10.1053/j.gastro.2019.04.013

PMID 30998992

发布时间 2020-08-01

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High-Fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett's Esophagus via Interleukin 8 and Alterations to the Gut Microbiome.

Gastroenterology

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High-Fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett's Esophagus via Interleukin 8 and Alterations to the Gut Microbiome.

Gastroenterology

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Gastroenterology

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