Attenuation of a dengue virus replicon by codon deoptimization of nonstructural genes.

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第一作者： Gayathri,Manokaran

第一单位： Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia; Institute of Vector Borne Disease, Monash University, Clayton, Victoria, Australia.

作者： Gayathri,Manokaran ^[1] ; Sujatmoko ^[2] ; Kirsty Grace,McPherson ^[2] ; Cameron Paul,Simmons ^[3]

作者单位： Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia; Institute of Vector Borne Disease, Monash University, Clayton, Victoria, Australia. ^[1] Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia. ^[2] Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia; Institute of Vector Borne Disease, Monash University, Clayton, Victoria, Australia; Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, District 5, Ho Chi Minh City, Viet Nam. Electronic address: cameron.simmons@worldmosquito.org. ^[3]

关键词 Attenuation Codon deoptimization Dengue Replicon Vaccine