The Chemogenetic Receptor Ligand Clozapine N-Oxide Induces <i>in vivo</i> Neuroreceptor Occupancy and Reduces Striatal Glutamate Levels.

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作者： Simone,Bærentzen ^[1] ; Agata,Casado-Sainz ^[2] ; Denise,Lange ^[1] ; Vladimir,Shalgunov ^[1] ; Isabel Martinez,Tejada ^[3] ; Mengfei,Xiong ^[4] ; Elina T,L'Estrade ^[1] ; Fraser G,Edgar ^[1] ; Hedok,Lee ^[4] ; Matthias M,Herth ^[1] ; Mikael,Palner ^[4]

作者单位： Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark. ^[1] Center for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark. ^[2] Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany. ^[3] Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark. ^[4] Radiation Physics, Nuclear Medicine Physics Unit, Skånes University Hospital, Lund, Sweden. ^[5] Department of Anesthesiology and Pediatric Anesthesiology, Yale University, New Haven, CT, United States. ^[6] Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital, Copenhagen, Denmark. ^[7]

关键词 CNO DREADD clozapine dopamine receptors glutamate serotonin receptors

DOI 10.3389/fnins.2019.00187

PMID 31001069

发布时间 2020-09-29

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Frontiers in neuroscience

2019年13卷

187页

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The Chemogenetic Receptor Ligand Clozapine N-Oxide Induces <i>in vivo</i> Neuroreceptor Occupancy and Reduces Striatal Glutamate Levels.

Frontiers in neuroscience

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Frontiers in neuroscience

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The Chemogenetic Receptor Ligand Clozapine N-Oxide Induces <i>in vivo</i> Neuroreceptor Occupancy and Reduces Striatal Glutamate Levels.

Frontiers in neuroscience

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Frontiers in neuroscience

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