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Olanzapine: A potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics.

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第一作者： Mikail,Weston

第一单位： Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK.

作者： Mikail,Weston ^[1] ; Teresa,Kaserer ^[2] ; Angela,Wu ^[3] ; Alexandre,Mouravlev ^[3] ; Jenna C,Carpenter ^[1] ; Albert,Snowball ^[1] ; Samuel,Knauss ^[1] ; Melanie,von Schimmelmann ^[4] ; Matthew J,During ^[4] ; Gabriele,Lignani ^[1] ; Stephanie,Schorge ^[1] ; Deborah,Young ^[3] ; Dimitri M,Kullmann ^[1] ; Andreas,Lieb ^[1]

作者单位： Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK. ^[1] Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, UK. ^[2] Department of Pharmacology & Clinical Pharmacology, The University of Auckland, Auckland, New Zealand. ^[3] Ovid Therapeutics, Inc., 1460 Broadway, New York, NY 10036, USA. ^[4]

医学主题词计算机模拟(Computer Simulation);改制药物(Designer Drugs);高通量筛选分析(High-Throughput Screening Assays);人类(Humans);受体, 毒蕈碱M4(Receptor, Muscarinic M4);信号传导(Signal Transduction)

DOI 10.1126/sciadv.aaw1567

PMID 31001591

发布时间 2025-05-30

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Olanzapine: A potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics.

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Olanzapine: A potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics.

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