首页> The Journal of biological chemistry> Stella protein facilitates DNA demethylation by disrupting the chromatin association of the RING finger-type E3 ubiquitin ligase UHRF1.

Stella protein facilitates DNA demethylation by disrupting the chromatin association of the RING finger-type E3 ubiquitin ligase UHRF1.

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第一作者： Wenlong,Du

第一单位： From the College of Life Sciences, Beijing Normal University, Beijing 100875.;the National Institute of Biological Sciences, Beijing 102206.;the National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101.

作者： Wenlong,Du ^[1] ; Qiang,Dong ^[2] ; Zhuqiang,Zhang ^[2] ; Baodong,Liu ^[3] ; Ting,Zhou ^[2] ; Rui-Ming,Xu ^[4] ; Hailin,Wang ^[3] ; Bing,Zhu ^[4] ; Yingfeng,Li ^[5]

作者单位： From the College of Life Sciences, Beijing Normal University, Beijing 100875.;the National Institute of Biological Sciences, Beijing 102206.;the National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101. ^[1] the National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101. ^[2] the State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, and. ^[3] the National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101.;the College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China. ^[4] the National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, liyingfeng@nibs.ac.cn. ^[5]

关键词 DNA demethylation DNA methylation FRAP assay Stella chromatin association developmental pluripotency associated 3 (DPPA3)epigenetics gene regulation protein-protein interaction ubiquitin-like with PHD and RING finger domains 1 (UHRF1)