Genome-wide CRISPR knockout screens identify NCAPG as an essential oncogene for hepatocellular carcinoma tumor growth.

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作者： Yu,Wang ^[1] ; Bin,Gao ^[1] ; Peng Yang,Tan ^[1] ; Yohana Ayupriyanti,Handoko ^[1] ; Karthik,Sekar ^[1] ; Amudha,Deivasigamani ^[1] ; Veerabrahma Pratap,Seshachalam ^[1] ; Han-Yue,OuYang ^[2] ; Ming,Shi ^[2] ; Chan,Xie ^[3] ; Brian Kim Poh,Goh ^[4] ; London Lucien,Ooi ^[5] ; Kam,Man Hui ^[6]

作者单位： Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore. ^[1] Department of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China. ^[2] Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. ^[3] Department of Hepato-Pancreato-Biliary and Transplant Surgery, Singapore General Hospital, Singapore. ^[4] Department of Hepato-Pancreato-Biliary and Transplant Surgery, Singapore General Hospital, Singapore.;Division of Surgical Oncology, National Cancer Centre Singapore, Singapore. ^[5] Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore.;Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore.;Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), Singapore.;Duke-NUS Medical School, Singapore. ^[6]

关键词 cell cycle therapeutic target tumor recurrence