Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parallel-group, phase II-III, randomised, superiority study (CAIRO6)
作者:
Koen P,Rovers [1]
;
Checca,Bakkers [1]
;
Geert A A M,Simkens [1]
;
Jacobus W A,Burger [1]
;
Simon W,Nienhuijs [1]
;
Geert-Jan M,Creemers [2]
;
Anna M J,Thijs [2]
;
Alexandra R M,Brandt-Kerkhof [3]
;
Eva V E,Madsen [3]
;
Ninos,Ayez [3]
;
Nadine L,de Boer [3]
;
Esther,van Meerten [4]
;
Jurriaan B,Tuynman [5]
;
Miranda,Kusters [5]
;
Nina R,Sluiter [5]
;
Henk M W,Verheul [6]
;
Hans J,van der Vliet [6]
;
Marinus J,Wiezer [7]
;
Djamila,Boerma [7]
;
Emma C E,Wassenaar [7]
;
Maartje,Los [8]
;
Cornelis B,Hunting [8]
;
Arend G J,Aalbers [9]
;
Niels F M,Kok [9]
;
Koert F D,Kuhlmann [9]
;
Henk,Boot [10]
;
Myriam,Chalabi [10]
;
Schelto,Kruijff [11]
;
Lukas B,Been [11]
;
Robert J,van Ginkel [11]
;
Derk Jan A,de Groot [12]
;
Rudolf S N,Fehrmann [12]
;
Johannes H W,de Wilt [13]
;
Andreas J A,Bremers [13]
;
Philip R,de Reuver [13]
;
Sandra A,Radema [14]
;
Karin H,Herbschleb [14]
;
Wilhelmina M U,van Grevenstein [15]
;
Arjen J,Witkamp [15]
;
Miriam,Koopman [16]
;
Nadia,Haj Mohammad [16]
;
Eino B,van Duyn [17]
;
Walter J B,Mastboom [17]
;
Leonie J M,Mekenkamp [18]
;
Joost,Nederend [19]
;
Max J,Lahaye [20]
;
Petur,Snaebjornsson [21]
;
Cornelis,Verhoef [3]
;
Hanneke W M,van Laarhoven [22]
;
Aeilko H,Zwinderman [23]
;
Jeanette M,Bouma [24]
;
Onno,Kranenburg [25]
;
Iris,van 't Erve [21]
;
Remond J A,Fijneman [21]
;
Marcel G W,Dijkgraaf [23]
;
Patrick H J,Hemmer [11]
;
Cornelis J A,Punt [22]
;
Pieter J,Tanis [26]
;
Ignace H J T,de Hingh [27]
;
Dutch Peritoneal Oncology Group (DPOG) ;
Dutch Colorectal Cancer Group (DCCG)
作者单位:
Department of Surgery, Catharina Hospital, PO Box 1350, 5602 ZA, Eindhoven, Netherlands.
[1]
Department of Medical Oncology, Catharina Hospital, PO Box 1350, 5602, Eindhoven, ZA, Netherlands.
[2]
Department of Surgical Oncology, Erasmus Medical Centre, PO Box 2040, 3000, Rotterdam, CA, Netherlands.
[3]
Department of Medical Oncology, Erasmus MC Cancer Institute, PO Box 2040, 3000, Rotterdam, CA, Netherlands.
[4]
Department of Surgery, Amsterdam University Medical Centres, Location VUMC, PO Box 7057, 1007, Amsterdam, MB, Netherlands.
[5]
Department of Medical Oncology, Amsterdam University Medical Centres, Location VUMC, PO Box 7057, 1007, Amsterdam, MB, Netherlands.
[6]
Department of Surgery, St. Antonius Hospital, PO Box 2500, 3430, Nieuwegein, EM, Netherlands.
[7]
Department of Medical Oncology, St. Antonius Hospital, PO Box 2500, 3430, Nieuwegein, EM, Netherlands.
[8]
Department of Surgical Oncology, Netherlands Cancer Institute, PO Box 90203, 1006, Amsterdam, BE, Netherlands.
[9]
Department of Gastrointestinal Oncology, Netherlands Cancer Institute, PO Box 90203, 1006, Amsterdam, BE, Netherlands.
[10]
Department of Surgery, University Medical Centre Groningen, PO Box 30001, 9700 RB, Groningen, RB, Netherlands.
[11]
Department of Medical Oncology, University Medical Centre Groningen, PO Box 30001, 9700, Groningen, RB, Netherlands.
[12]
Department of Surgery, Radboud University Medical Centre, PO Box 9101, 6500, Nijmegen, HB, Netherlands.
[13]
Department of Medical Oncology, Radboud University Medical Centre, PO Box 9101, 6500, Nijmegen, HB, Netherlands.
[14]
Department of Surgery, University Medical Centre Utrecht, PO Box 85500, 3508, Utrecht, GA, Netherlands.
[15]
Department of Medical Oncology, University Medical Centre Utrecht, PO Box 85500, 3508, Utrecht, GA, Netherlands.
[16]
Department of Surgery, Medisch Spectrum Twente, PO Box 50000, 7500, Enschede, KA, Netherlands.
[17]
Department of Medical Oncology, Medisch Spectrum Twente, PO Box 50000, 7500, Enschede, KA, Netherlands.
[18]
Department of Radiology, Catharina Hospital, PO Box 1350, 5602, Eindhoven, ZA, Netherlands.
[19]
Department of Radiology, Netherlands Cancer Institute, PO Box 90203, 1006, Amsterdam, BE, Netherlands.
[20]
Department of Pathology, Netherlands Cancer Institute, PO Box 90203, 1006, Amsterdam, BE, Netherlands.
[21]
Department of Medical Oncology, Amsterdam University Medical Centres, Location AMC, PO Box 22660, 1100, Amsterdam, DD, Netherlands.
[22]
Department of Clinical Epidemiology, Biostatistics & Bioinformatics, Amsterdam University Medical Centres, Location AMC, PO Box 22660, 1100, Amsterdam, DD, Netherlands.
[23]
Clinical Trial Department, Netherlands Comprehensive Cancer Organisation (IKNL), PO Box 19079, 3501, Utrecht, DB, Netherlands.
[24]
UMC Utrecht Cancer Centre, University Medical Centre Utrecht, PO Box 85500, 3508, Utrecht, GA, Netherlands.
[25]
Department of Surgery, Amsterdam University Medical Centres, Location AMC, PO Box 22660, 1100, Amsterdam, DD, Netherlands.
[26]
Department of Surgery, Catharina Hospital, PO Box 1350, 5602 ZA, Eindhoven, Netherlands. ignace.d.hingh@catharinaziekenhuis.nl.
[27]
主题词
成年人(Adult);化学疗法, 辅助(Chemotherapy, Adjuvant);结直肠肿瘤(Colorectal Neoplasms);综合疗法(Combined Modality Therapy);无病生存(Disease-Free Survival);女(雌)性(Female);氟尿嘧啶(Fluorouracil);人类(Humans);醛氢叶酸(Leucovorin);男(雄)性(Male);中年人(Middle Aged);肿瘤转移(Neoplasm Metastasis);围手术期(Perioperative Period);腹膜肿瘤(Peritoneal Neoplasms);腹膜(Peritoneum);生活质量(Quality of Life)
DOI
10.1186/s12885-019-5545-0
PMID
31023318
发布时间
2020-03-09
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BMC cancer
BMC cancer
390页
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