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Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parallel-group, phase II-III, randomised, superiority study (CAIRO6)

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作者: Koen P,Rovers [1] ; Checca,Bakkers [1] ; Geert A A M,Simkens [1] ; Jacobus W A,Burger [1] ; Simon W,Nienhuijs [1] ; Geert-Jan M,Creemers [2] ; Anna M J,Thijs [2] ; Alexandra R M,Brandt-Kerkhof [3] ; Eva V E,Madsen [3] ; Ninos,Ayez [3] ; Nadine L,de Boer [3] ; Esther,van Meerten [4] ; Jurriaan B,Tuynman [5] ; Miranda,Kusters [5] ; Nina R,Sluiter [5] ; Henk M W,Verheul [6] ; Hans J,van der Vliet [6] ; Marinus J,Wiezer [7] ; Djamila,Boerma [7] ; Emma C E,Wassenaar [7] ; Maartje,Los [8] ; Cornelis B,Hunting [8] ; Arend G J,Aalbers [9] ; Niels F M,Kok [9] ; Koert F D,Kuhlmann [9] ; Henk,Boot [10] ; Myriam,Chalabi [10] ; Schelto,Kruijff [11] ; Lukas B,Been [11] ; Robert J,van Ginkel [11] ; Derk Jan A,de Groot [12] ; Rudolf S N,Fehrmann [12] ; Johannes H W,de Wilt [13] ; Andreas J A,Bremers [13] ; Philip R,de Reuver [13] ; Sandra A,Radema [14] ; Karin H,Herbschleb [14] ; Wilhelmina M U,van Grevenstein [15] ; Arjen J,Witkamp [15] ; Miriam,Koopman [16] ; Nadia,Haj Mohammad [16] ; Eino B,van Duyn [17] ; Walter J B,Mastboom [17] ; Leonie J M,Mekenkamp [18] ; Joost,Nederend [19] ; Max J,Lahaye [20] ; Petur,Snaebjornsson [21] ; Cornelis,Verhoef [3] ; Hanneke W M,van Laarhoven [22] ; Aeilko H,Zwinderman [23] ; Jeanette M,Bouma [24] ; Onno,Kranenburg [25] ; Iris,van 't Erve [21] ; Remond J A,Fijneman [21] ; Marcel G W,Dijkgraaf [23] ; Patrick H J,Hemmer [11] ; Cornelis J A,Punt [22] ; Pieter J,Tanis [26] ; Ignace H J T,de Hingh [27] ; Dutch Peritoneal Oncology Group (DPOG) ; Dutch Colorectal Cancer Group (DCCG)
作者单位: Department of Surgery, Catharina Hospital, PO Box 1350, 5602 ZA, Eindhoven, Netherlands. [1] Department of Medical Oncology, Catharina Hospital, PO Box 1350, 5602, Eindhoven, ZA, Netherlands. [2] Department of Surgical Oncology, Erasmus Medical Centre, PO Box 2040, 3000, Rotterdam, CA, Netherlands. [3] Department of Medical Oncology, Erasmus MC Cancer Institute, PO Box 2040, 3000, Rotterdam, CA, Netherlands. [4] Department of Surgery, Amsterdam University Medical Centres, Location VUMC, PO Box 7057, 1007, Amsterdam, MB, Netherlands. [5] Department of Medical Oncology, Amsterdam University Medical Centres, Location VUMC, PO Box 7057, 1007, Amsterdam, MB, Netherlands. [6] Department of Surgery, St. Antonius Hospital, PO Box 2500, 3430, Nieuwegein, EM, Netherlands. [7] Department of Medical Oncology, St. Antonius Hospital, PO Box 2500, 3430, Nieuwegein, EM, Netherlands. [8] Department of Surgical Oncology, Netherlands Cancer Institute, PO Box 90203, 1006, Amsterdam, BE, Netherlands. [9] Department of Gastrointestinal Oncology, Netherlands Cancer Institute, PO Box 90203, 1006, Amsterdam, BE, Netherlands. [10] Department of Surgery, University Medical Centre Groningen, PO Box 30001, 9700 RB, Groningen, RB, Netherlands. [11] Department of Medical Oncology, University Medical Centre Groningen, PO Box 30001, 9700, Groningen, RB, Netherlands. [12] Department of Surgery, Radboud University Medical Centre, PO Box 9101, 6500, Nijmegen, HB, Netherlands. [13] Department of Medical Oncology, Radboud University Medical Centre, PO Box 9101, 6500, Nijmegen, HB, Netherlands. [14] Department of Surgery, University Medical Centre Utrecht, PO Box 85500, 3508, Utrecht, GA, Netherlands. [15] Department of Medical Oncology, University Medical Centre Utrecht, PO Box 85500, 3508, Utrecht, GA, Netherlands. [16] Department of Surgery, Medisch Spectrum Twente, PO Box 50000, 7500, Enschede, KA, Netherlands. [17] Department of Medical Oncology, Medisch Spectrum Twente, PO Box 50000, 7500, Enschede, KA, Netherlands. [18] Department of Radiology, Catharina Hospital, PO Box 1350, 5602, Eindhoven, ZA, Netherlands. [19] Department of Radiology, Netherlands Cancer Institute, PO Box 90203, 1006, Amsterdam, BE, Netherlands. [20] Department of Pathology, Netherlands Cancer Institute, PO Box 90203, 1006, Amsterdam, BE, Netherlands. [21] Department of Medical Oncology, Amsterdam University Medical Centres, Location AMC, PO Box 22660, 1100, Amsterdam, DD, Netherlands. [22] Department of Clinical Epidemiology, Biostatistics & Bioinformatics, Amsterdam University Medical Centres, Location AMC, PO Box 22660, 1100, Amsterdam, DD, Netherlands. [23] Clinical Trial Department, Netherlands Comprehensive Cancer Organisation (IKNL), PO Box 19079, 3501, Utrecht, DB, Netherlands. [24] UMC Utrecht Cancer Centre, University Medical Centre Utrecht, PO Box 85500, 3508, Utrecht, GA, Netherlands. [25] Department of Surgery, Amsterdam University Medical Centres, Location AMC, PO Box 22660, 1100, Amsterdam, DD, Netherlands. [26] Department of Surgery, Catharina Hospital, PO Box 1350, 5602 ZA, Eindhoven, Netherlands. ignace.d.hingh@catharinaziekenhuis.nl. [27]
DOI 10.1186/s12885-019-5545-0
PMID 31023318
发布时间 2020-03-09
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