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Hepatocellular Carcinoma: Etiology and Current and Future Drugs.

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作者: Aastha,Jindal [1] ; Anusha,Thadi [1] ; Kunwar,Shailubhai [1]
作者单位: Research and Development Center, Baruch S. Blumberg Institute, Doylestown, PA 18902, USA. [1] Research & Development, Tiziana Lifesciences, Doylestown, PA 18902, USA. [2]
关键词 AMP, adenosine monophosphateAMPK, AMP-activated protein kinaseATP, adenosine 5′-triphosphateBMF, Bcl2 modifying factorBMI, body mass indexCDK, cyclin-dependent kinaseCTGF, connective tissue growth factorCTL, cytotoxic T lymphocyteCTLA, cytotoxic T-lymphocyte-associated proteinECM, extracellular matrixEFGR, endothelial growth factor receptorEGFR, epidermal growth factor receptorEMT, Epithelial–mesenchymal transitionERK, extracellular signal-regulated kinaseFDA, Food and Drug AdministrationGFG, fibroblast growth factorHBV, hepatitis B virusHBcAg, hepatitis B core antibodyHBsAg, HBV surface antigenHCC, Hepatocellular carcinomaHCV, hepatitis B virusHDV, hepatitis D virusHIF, hypoxia-inducible factorHIV, human immunodeficiency virusIGFR, insulin-like growth factorJAK, janus kinaseMAPK, mitogen-activated protein kinaseMDSC, myeloid-derived suppressor cellNASH, nonalcoholic steatohepatitisNK, natural killerNKT, natural killer T cellORR, objective response rateOS, overall survivalPAPSS1, 3′-phosphoadenosine 5′-phosphosulfate synthase 1PD-L1, programmed death ligand1PD1, programmed cell death protein 1PDGFR, platelet-derived growth factor receptorPEDF, pigment epithelium-derived factorPFS, progression-free survivalPI3K, phosphoinositide 3-kinasesPTEN, phosphatase and tensin homologPUMA, p53 upregulated modulator of apoptosisRFA, radiofrequency ablationRb, retinoblastoma proteinSCF, stem cell factorSHP1, src homology 2 domain–containing phosphatase 1STAT3, signal transducer and activator of transcription 3TACE, transarterial chemoembolizationTGF 1, transforming growth factor-1TK, tyrosine kinaseTKI, Tyrosine kinase inhibitorTRKA, tropomyosin receptor kinase ATreg, regulatory T cellsVEGF, vascular endothelial growth factorVEGFR, vascular endothelial growth factor receptorbFGF, basic fibroblast growth factorcombination therapycyclin-dependent kinase inhibitorshepatocellular carcinomahepatologytyrosine kinase inhibitors
DOI 10.1016/j.jceh.2019.01.004
PMID 31024205
发布时间 2020-09-28
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