Mycobacteria-Specific Mono- and Polyfunctional CD4+ T Cell Profiles in Children With Latent and Active Tuberculosis: A Prospective Proof-of-Concept Study.

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作者： Marc,Tebruegge ^[1] ; Nicole,Ritz ^[2] ; Susan,Donath ^[3] ; Binita,Dutta ^[4] ; Benjamin,Forbes ^[1] ; Vanessa,Clifford ^[5] ; Christel,Zufferey ^[1] ; Robert,De Rose ^[6] ; Roy M,Robins-Browne ^[7] ; Willem,Hanekom ^[7] ; Stephen M,Graham ^[1] ; Tom,Connell ^[7] ; Nigel,Curtis ^[8]

作者单位： Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia. ^[1] UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom. ^[2] Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine & Global Health Research Institute, University of Southampton, Southampton, United Kingdom. ^[3] Department of Paediatric Infectious Diseases & Immunology, Evelina London Children's Hospital, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom. ^[4] Infectious Diseases and Pharmacology Unit, University of Basel Children's Hospital, Basel, Switzerland. ^[5] Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Parkville, VIC, Australia. ^[6] Infectious Diseases Group, Murdoch Children's Research Institute, Parkville, VIC, Australia. ^[7] Infectious Diseases Unit, Royal Children's Hospital Melbourne, Parkville, VIC, Australia. ^[8] Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC, Australia. ^[9] Institute of Infectious Diseases and Molecular Medicine and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa. ^[10] Centre for International Child Health, Parkville, VIC, Australia. ^[11] International Child Health Group, Murdoch Children's Research Institute, Parkville, VIC, Australia. ^[12]

关键词 T cell child diagnosis functional profile immunoassay tuberculosis