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Codon and Codon-Pair Usage Tables (CoCoPUTs): Facilitating Genetic Variation Analyses and Recombinant Gene Design.

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第一作者： Aikaterini,Alexaki

第一单位： Division of Plasma Protein Therapeutics, Office of Tissue and Advanced Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA.

作者： Aikaterini,Alexaki ^[1] ; Jacob,Kames ^[1] ; David D,Holcomb ^[1] ; John,Athey ^[1] ; Luis V,Santana-Quintero ^[2] ; Phuc Vihn Nguyen,Lam ^[2] ; Nobuko,Hamasaki-Katagiri ^[1] ; Ekaterina,Osipova ^[2] ; Vahan,Simonyan ^[2] ; Haim,Bar ^[3] ; Anton A,Komar ^[4] ; Chava,Kimchi-Sarfaty ^[5]

作者单位： Division of Plasma Protein Therapeutics, Office of Tissue and Advanced Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA. ^[1] High Performance Integrated Environment, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA. ^[2] Department of Statistics, University of Connecticut, Storrs, CT 06268, USA. ^[3] Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH 44115, USA. Electronic address: a.komar@csuohio.edu. ^[4] Division of Plasma Protein Therapeutics, Office of Tissue and Advanced Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA. Electronic address: Chava.kimchi-sarfaty@fda.hhs.gov. ^[5]

关键词 GenBank codon context codon-pair bias dinucleotide frequency gene optimization/deoptimization

医学主题词算法(Algorithms);碱基序列(Base Sequence);计算生物学(Computational Biology);数据库, 遗传学(Databases, Genetic);遗传变异(Genetic Variation);人类(Humans)

DOI 10.1016/j.jmb.2019.04.021

PMID 31029701

发布时间 2020-06-05

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准确一般字义偏差语意偏离译文作用小提交