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首页> International immunopharmacology> Neuroprotective effects of isoliquiritigenin against cognitive impairment via suppression of synaptic dysfunction, neuronal injury, and neuroinflammation in rats with kainic acid-induced seizures.

Neuroprotective effects of isoliquiritigenin against cognitive impairment via suppression of synaptic dysfunction, neuronal injury, and neuroinflammation in rats with kainic acid-induced seizures.

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作者： Xiaobo,Zhu ^[1] ; Jiankun,Liu ^[2] ; Shanying,Huang ^[3] ; Weiwei,Zhu ^[4] ; Yibiao,Wang ^[1] ; Ou,Chen ^[5] ; Jiang,Xue ^[6]

作者单位： Department of Pediatrics, the Second Hospital of Shandong University, Jinan 250012, China. ^[1] Department of Ophthalmology, the Second People's Hospital of Jinan City, Jinan 250000, China. ^[2] The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Shandong University, Jinan 250012, China. ^[3] Department of Pediatrics, Jinan Central Hospital Affiliated to Shandong University, Jinan 250000, China. ^[4] Department of Pediatrics, the Second Hospital of Shandong University, Jinan 250012, China; Nursing School, Shandong University, Jinan 250012, China. Electronic address: drchenou@126.com. ^[5] Department of Pediatrics, the Second Hospital of Shandong University, Jinan 250012, China. Electronic address: drxuejiang@hotmail.com. ^[6]

关键词 Cognitive impairment Epileptogenesis Isoliquiritigenin Kainic acid Neuroprotection Rat

主题词动物(Animals);消炎药(Anti-Inflammatory Agents);查耳酮类(Chalcones);脑炎(Encephalitis);海马(Hippocampus);炎性体(Inflammasomes);红藻氨酸(Kainic Acid);男(雄)性(Male);NF-E2相关因子2(NF-E2-Related Factor 2);神经元(Neurons);神经保护药(Neuroprotective Agents);大鼠, Wistar(Rats, Wistar);发作(Seizures);突触(Synapses)

DOI 10.1016/j.intimp.2019.04.028

PMID 31030091

发布时间 2020-01-07

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International immunopharmacology

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