Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase.

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作者： Tatsuo,Yanagisawa ^[1] ; Mitsuo,Kuratani ^[2] ; Eiko,Seki ^[3] ; Nobumasa,Hino ^[4] ; Kensaku,Sakamoto ^[5] ; Shigeyuki,Yokoyama ^[6]

作者单位： RIKEN Structural Biology Laboratory, 1-7-22 Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan; Laboratory for Nonnatural Amino Acid Technology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan. Electronic address: tatsuo.yanagisawa@riken.jp. ^[1] RIKEN Structural Biology Laboratory, 1-7-22 Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan. ^[2] RIKEN Structural Biology Laboratory, 1-7-22 Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan; RIKEN Cluster for Science, Technology and Innovation Hub, 1-7-22 Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan. ^[3] Laboratory of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. ^[4] Division of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan; Laboratory for Nonnatural Amino Acid Technology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan. ^[5] RIKEN Structural Biology Laboratory, 1-7-22 Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan; RIKEN Cluster for Science, Technology and Innovation Hub, 1-7-22 Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan. Electronic address: yokoyama@riken.jp. ^[6]

关键词 aminoacyl-tRNA synthetase crystal structure genetic code expansion lysine derivatives non-natural amino acid pyrrolysyl-tRNA synthetase specificity structural basis tRNA translation

主题词氨酰基tRNA合成酶类(Amino Acyl-tRNA Synthetases);结晶学, X线(Crystallography, X-Ray);大肠杆菌(Escherichia coli);遗传密码(Genetic Code);赖氨酸(Lysine);甲烷八叠球菌属(Methanosarcina);模型, 分子(Models, Molecular);蛋白质工程(Protein Engineering);RNA, 转移(RNA, Transfer)

DOI 10.1016/j.chembiol.2019.03.008

PMID 31031143

发布时间 2020-07-20

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Cell chemical biology

2019年26卷7期

936-949.e13页

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Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase.

Cell chemical biology

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Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase.

Cell chemical biology

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Cell chemical biology

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