Small molecule PROTACs in targeted therapy: An emerging strategy to induce protein degradation.

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作者： Meiyang,Xi ^[1] ; Yi,Chen ^[1] ; Hongyu,Yang ^[2] ; Huiting,Xu ^[1] ; Kui,Du ^[1] ; Chunlei,Wu ^[1] ; Yanfei,Xu ^[1] ; Liping,Deng ^[1] ; Xiang,Luo ^[1] ; Lemao,Yu ^[1] ; Yonghua,Wu ^[1] ; Xiaozhong,Gao ^[1] ; Tao,Cai ^[1] ; Bin,Chen ^[1] ; Runpu,Shen ^[3] ; Haopeng,Sun ^[4]

作者单位： College of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing, 312000, China. ^[1] Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China. ^[2] College of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing, 312000, China. Electronic address: srunpu@usx.edu.cn. ^[3] Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: sunhaopeng@163.com. ^[4]

关键词 Degradation E3 ligase PROTACs Proteasome

主题词动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);人类(Humans);配体(Ligands);寡肽类(Oligopeptides);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);蛋白质结合(Protein Binding);蛋白质类(Proteins);泛素蛋白连接酶类(Ubiquitin-Protein Ligases);泛素化(Ubiquitination)

DOI 10.1016/j.ejmech.2019.04.036

PMID 31035238

发布时间 2019-06-17

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European journal of medicinal chemistry

2019年174卷

159-180页

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Small molecule PROTACs in targeted therapy: An emerging strategy to induce protein degradation.

European journal of medicinal chemistry

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European journal of medicinal chemistry

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Small molecule PROTACs in targeted therapy: An emerging strategy to induce protein degradation.

European journal of medicinal chemistry

相似文献

European journal of medicinal chemistry

相关期刊

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