miR-140-5p could suppress tumor proliferation and progression by targeting TGFBRI/SMAD2/3 and IGF-1R/AKT signaling pathways in Wilms' tumor.
作者:
主题词
细胞系, 肿瘤(Cell Line, Tumor);细胞运动(Cell Movement);细胞增殖(Cell Proliferation);儿童(Child);疾病恶化(Disease Progression);减量调节(Down-Regulation);基因表达谱(Gene Expression Profiling);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);基因调控网络(Gene Regulatory Networks);人类(Humans);微RNAs(MicroRNAs);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);受体, IGF1型(Receptor, IGF Type 1);受体, 生长调节素(Receptors, Somatomedin);信号传导(Signal Transduction);Smad2蛋白质(Smad2 Protein);Smad3蛋白质(Smad3 Protein);Wilms瘤(Wilms Tumor)
DOI
10.1186/s12885-019-5609-1
PMID
31035970
发布时间
2020-12-09
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BMC cancer
405页
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