Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies.

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第一作者： Amit,Berson

第一单位： Department of Biology, University of Pennsylvania, Philadelphia, PA, 19104, USA.

作者： Amit,Berson ^[1] ; Lindsey D,Goodman ^[2] ; Ashley N,Sartoris ^[1] ; Charlton G,Otte ^[1] ; James A,Aykit ^[1] ; Virginia M-Y,Lee ^[3] ; John Q,Trojanowski ^[3] ; Nancy M,Bonini ^[4]

作者单位： Department of Biology, University of Pennsylvania, Philadelphia, PA, 19104, USA. ^[1] Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. ^[2] Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. ^[3] Department of Biology, University of Pennsylvania, Philadelphia, PA, 19104, USA. nbonini@sas.upenn.edu. ^[4]

关键词 ALYREF Amyotrophic lateral sclerosis (ALS) (Lou Gehrig disease)Ataxin-2 C9orf72 Drosophila Neurodegeneration Nuclear transport Ref1 TAR DNA-binding protein 43 (TDP-43) (TARDBP)mRNA

主题词肌萎缩侧索硬化(Amyotrophic Lateral Sclerosis);动物(Animals);DNA结合蛋白质类(DNA-Binding Proteins);减量调节(Down-Regulation);果蝇属(Drosophila);果蝇蛋白质类(Drosophila Proteins);女(雌)性(Female);额颞叶痴呆(Frontotemporal Dementia);基因表达调控(Gene Expression Regulation);人类(Humans);男(雄)性(Male);运动神经元(Motor Neurons);核蛋白质类(Nuclear Proteins);RNA, 信使(RNA, Messenger);RNA结合蛋白质类(RNA-Binding Proteins);转录因子(Transcription Factors);增量调节(Up-Regulation)

DOI 10.1186/s40478-019-0710-x

PMID 31036086

发布时间 2024-09-22

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Acta neuropathologica communications

2019年7卷1期

65页

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Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies.

Acta neuropathologica communications

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Acta neuropathologica communications

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Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies.

Acta neuropathologica communications

相似文献

Acta neuropathologica communications

相关期刊

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