首页> Proceedings of the National Academy of Sciences of the United States of America> Defining the core essential genome of <i>Pseudomonas aeruginosa</i>.

Defining the core essential genome of <i>Pseudomonas aeruginosa</i>.

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第一作者： Bradley E,Poulsen

第一单位： Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.;Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114.;Department of Genetics, Harvard Medical School, Boston, MA 02115.;Broad Institute of MIT and Harvard, Cambridge, MA 02142.

作者： Bradley E,Poulsen ^[1] ; Rui,Yang ^[2] ; Anne E,Clatworthy ^[3] ; Tiantian,White ^[4] ; Sarah J,Osmulski ^[4] ; Li,Li ^[4] ; Cristina,Penaranda ^[4] ; Eric S,Lander ^[5] ; Noam,Shoresh ^[2] ; Deborah T,Hung ^[6]

作者单位： Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.;Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114.;Department of Genetics, Harvard Medical School, Boston, MA 02115.;Broad Institute of MIT and Harvard, Cambridge, MA 02142. ^[1] Broad Institute of MIT and Harvard, Cambridge, MA 02142. ^[2] Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.;Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114.;Broad Institute of MIT and Harvard, Cambridge, MA 02142. ^[3] Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.;Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114. ^[4] Broad Institute of MIT and Harvard, Cambridge, MA 02142; lander@broadinstitute.org hung@molbio.mgh.harvard.edu.;Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.;Department of Systems Biology, Harvard Medical School, Boston, MA 02115. ^[5] Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114; lander@broadinstitute.org hung@molbio.mgh.harvard.edu.;Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114.;Department of Genetics, Harvard Medical School, Boston, MA 02115.;Broad Institute of MIT and Harvard, Cambridge, MA 02142. ^[6]

关键词 ESKAPE Tn-Seq antibiotic discovery gram-negative pathogens

主题词 DNA转座子(DNA Transposable Elements);基因, 必要(Genes, Essential);基因组, 细菌(Genome, Bacterial);模型, 统计学(Models, Statistical);铜绿假单胞菌(Pseudomonas aeruginosa)

DOI 10.1073/pnas.1900570116

PMID 31036669

发布时间 2024-09-22

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准确一般字义偏差语意偏离译文作用小提交