Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects.

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作者： Luisa,Klotz ^[1] ; Melanie,Eschborn ^[2] ; Maren,Lindner ^[2] ; Marie,Liebmann ^[2] ; Martin,Herold ^[2] ; Claudia,Janoschka ^[2] ; Belén,Torres Garrido ^[2] ; Andreas,Schulte-Mecklenbeck ^[2] ; Catharina C,Gross ^[2] ; Johanna,Breuer ^[2] ; Petra,Hundehege ^[2] ; Vilmos,Posevitz ^[2] ; Béatrice,Pignolet ^[3] ; Giulia,Nebel ^[4] ; Shirin,Glander ^[5] ; Nicole,Freise ^[6] ; Judith,Austermann ^[6] ; Timo,Wirth ^[2] ; Graham R,Campbell ^[7] ; Tilman,Schneider-Hohendorf ^[2] ; Maria,Eveslage ^[8] ; David,Brassat ^[3] ; Nicholas,Schwab ^[2] ; Karin,Loser ^[9] ; Johannes,Roth ^[6] ; Karin B,Busch ^[4] ; Monika,Stoll ^[5] ; Don J,Mahad ^[10] ; Sven G,Meuth ^[7] ; Timothy,Turner ^[2] ; Amit,Bar-Or ^[11] ; Heinz,Wiendl ^[12]

作者单位： University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany. luisa.klotz@ukmuenster.de. ^[1] University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany. ^[2] CRC-SEP, Neurosciences Department, Toulouse University Hospital and INSERM U1043 - CNRS UMR 5282, Centre de Physiopathologie Toulouse-Purpan, Université Toulouse III, 31300 Toulouse, France. ^[3] University of Münster, Institute of Molecular Cell Biology, 48149 Münster, Germany. ^[4] University of Münster, Department of Genetic Epidemiology, 48149 Münster, Germany. ^[5] University of Münster, Department of Immunology, 48149 Münster, Germany. ^[6] University of Edinburgh, Centre for Clinical Brain Sciences, EH8 9YL Edinburgh, UK. ^[7] University of Münster, Institute of Biostatistics and Clinical Research, 48149 Münster, Germany. ^[8] University Hospital Münster, Department of Dermatology, 48149 Münster, Germany. ^[9] Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, 6229 ER Maastricht, Netherlands. ^[10] Sanofi Genzyme, Cambridge, MA 02142, USA. ^[11] Center for Neuroinflammation and Experimental Therapeutics and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ^[12] Brain and Mind Centre, Medical Faculty, University of Sydney, Sydney, Camperdown, NSW 2050, Australia. ^[13]