The Molecular Basis for Apolipoprotein E4 as the Major Risk Factor for Late-Onset Alzheimer's Disease.

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第一作者： Ana-Caroline,Raulin

第一单位： Sussex Neuroscience, School of Life Sciences, University of Sussex, Falmer, Brighton, East Sussex BN1 6NN, UK.

作者： Ana-Caroline,Raulin ^[1] ; Lucas,Kraft ^[2] ; Youssra K,Al-Hilaly ^[3] ; Wei-Feng,Xue ^[4] ; John E,McGeehan ^[5] ; John R,Atack ^[2] ; Louise,Serpell ^[6]

作者单位： Sussex Neuroscience, School of Life Sciences, University of Sussex, Falmer, Brighton, East Sussex BN1 6NN, UK. ^[1] Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Falmer, Brighton, East Sussex , BN1 6NN, UK. ^[2] Sussex Neuroscience, School of Life Sciences, University of Sussex, Falmer, Brighton, East Sussex BN1 6NN, UK; Chemistry Department, College of Science, Mustansiriyah University, Baghdad, Iraq. ^[3] School of Biosciences, University of Kent, Canterbury, England CT2 7NJ, UK. ^[4] School of Biological Sciences, Institute of Biological and Biomedical Sciences, Faculty of Science, University of Portsmouth, Portsmouth, Hampshire PO1 2DY, UK. ^[5] Sussex Neuroscience, School of Life Sciences, University of Sussex, Falmer, Brighton, East Sussex BN1 6NN, UK. Electronic address: L.C.Serpell@sussex.ac.uk. ^[6]

关键词 Alzheimer's disease alpha-helix analytical ultracentrifugation apolipoprotein E small-angle x-ray scattering