首页> Journal of molecular graphics & modelling> Cryo-EM density map fitting driven in-silico structure of human soluble guanylate cyclase (hsGC) reveals functional aspects of inter-domain cross talk upon NO binding.

Cryo-EM density map fitting driven in-silico structure of human soluble guanylate cyclase (hsGC) reveals functional aspects of inter-domain cross talk upon NO binding.

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第一作者： Rana Rehan,Khalid

第一单位： Department of Biosciences, COMSATS University, Islamabad, 45550, Pakistan; Department of Biostatistics and Medical Informatics, Acibadem Universitesi, Istanbul, 34752, Turkey; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109-2218, USA. Electronic address: ray.binm@gmail.com.

作者： Rana Rehan,Khalid ^[1] ; Arooma,Maryam ^[2] ; Vasiliki E,Fadouloglou ^[3] ; Abdul Rauf,Siddiqi ^[4] ; Yang,Zhang ^[5]

作者单位： Department of Biosciences, COMSATS University, Islamabad, 45550, Pakistan; Department of Biostatistics and Medical Informatics, Acibadem Universitesi, Istanbul, 34752, Turkey; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109-2218, USA. Electronic address: ray.binm@gmail.com. ^[1] Department of Biosciences, COMSATS University, Islamabad, 45550, Pakistan; Department of Pharmaceutical Chemistry, Biruni Universitesi, Istanbul, 34010, Turkey. Electronic address: aroomabinm@yahoo.com. ^[2] Department of Molecular Biology and Genetics, Democritus University of Thrace, University Campus, Alexandroupolis, 68100, Greece. Electronic address: fadoulog@imbb.forth.gr. ^[3] Department of Biosciences, COMSATS University, Islamabad, 45550, Pakistan. Electronic address: araufsiddiqi@comsats.edu.pk. ^[4] Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109-2218, USA. Electronic address: zhng@umich.edu. ^[5]

关键词 Cryo-EM density map fitting Homology modelling Multi-domain assembly Protein-protein docking Single/multiple-chain threading

医学主题词氨基酸序列(Amino Acid Sequence);计算机模拟(Computer Simulation);冷冻电子显微镜检查(Cryoelectron Microscopy);血红素(Heme);人类(Humans);一氧化氮(Nitric Oxide);序列比对(Sequence Alignment);信号传导(Signal Transduction)

DOI 10.1016/j.jmgm.2019.04.009

PMID 31055154

发布时间 2023-11-11

基金项目

S10 OD026825/OD/NIH HHS/United States R01 GM083107/GM/NIGMS NIH HHS/United States R01 AI134678/AI/NIAID NIH HHS/United States R01 GM116960/GM/NIGMS NIH HHS/United States R35 GM136422/GM/NIGMS NIH HHS/United States

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