作者：
Jo,Ishizawa [1]
;
Sarah F,Zarabi [2]
;
R Eric,Davis [3]
;
Ondrej,Halgas [4]
;
Takenobu,Nii [1]
;
Yulia,Jitkova [5]
;
Ran,Zhao [1]
;
Jonathan,St-Germain [5]
;
Lauren E,Heese [1]
;
Grace,Egan [5]
;
Vivian R,Ruvolo [1]
;
Samir H,Barghout [2]
;
Yuki,Nishida [1]
;
Rose,Hurren [5]
;
Wencai,Ma [6]
;
Marcela,Gronda [5]
;
Todd,Link [7]
;
Keith,Wong [4]
;
Mark,Mabanglo [8]
;
Kensuke,Kojima [9]
;
Gautam,Borthakur [1]
;
Neil,MacLean [5]
;
Man Chun John,Ma [3]
;
Andrew B,Leber [5]
;
Mark D,Minden [2]
;
Walid,Houry [10]
;
Hagop,Kantarjian [11]
;
Martin,Stogniew [12]
;
Brian,Raught [2]
;
Emil F,Pai [13]
;
Aaron D,Schimmer [14]
;
Michael,Andreeff [15]
作者单位：
The University of Texas MD Anderson Cancer Center, Molecular Hematology and Therapy, Department of Leukemia, Houston, TX 77030, USA.
[1]
Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON M5G 1L7, Canada.
[2]
The University of Texas MD Anderson Cancer Center; Department of Lymphoma and Myeloma, Houston, TX 77030, USA.
[3]
Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.
[4]
Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
[5]
The University of Texas MD Anderson Cancer Center, Bioinformatics and Comp Biology, Houston, TX 77030, USA.
[6]
The University of Texas MD Anderson Cancer Center, Genomic Medicine, Houston, TX 77030, USA.
[7]
Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.
[8]
The University of Texas MD Anderson Cancer Center, Molecular Hematology and Therapy, Department of Leukemia, Houston, TX 77030, USA; Saga University, Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Saga 849-8501, Japan.
[9]
Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.
[10]
The University of Texas MD Anderson Cancer Center; Department of Leukemia, Houston, TX 77030, USA.
[11]
Oncoceutics, Inc., Philadelphia, PA 19104, USA.
[12]
Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
[13]
Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON M5G 1L7, Canada. Electronic address: aaron.schimmer@uhn.ca.
[14]
The University of Texas MD Anderson Cancer Center, Molecular Hematology and Therapy, Department of Leukemia, Houston, TX 77030, USA; The University of Texas MD Anderson Cancer Center; Department of Leukemia, Houston, TX 77030, USA. Electronic address: mandreef@mdanderson.org.
[15]
主题词
动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);结晶学, X线(Crystallography, X-Ray);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);内肽酶Clp(Endopeptidase Clp);女(雌)性(Female);HCT116细胞(HCT116 Cells);HEK293细胞(HEK293 Cells);人类(Humans);咪唑类(Imidazoles);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);小鼠(Mice);线粒体(Mitochondria);模型, 分子(Models, Molecular);点突变(Point Mutation);蛋白质构象(Protein Conformation);吡啶类(Pyridines);嘧啶类(Pyrimidines);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1016/j.ccell.2019.03.014
PMID
31056398
发布时间
2020-12-09
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