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首页> The AAPS journal> Fc-Fusion Drugs Have FcγR/C1q Binding and Signaling Properties That May Affect Their Immunogenicity.

Fc-Fusion Drugs Have FcγR/C1q Binding and Signaling Properties That May Affect Their Immunogenicity.

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作者： H A Daniel,Lagassé ^[1] ; Hartmut,Hengel ^[2] ; Basil,Golding ^[3] ; Zuben E,Sauna ^[1]

作者单位： Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., White Oak Building 52/72, Room 4120, Silver Spring, MD, 20993-0002, USA. ^[1] Institute of Virology, University Medical Center, Freiburg, Germany. ^[2] Faculty of Medicine, Albert-Ludwigs-University, Freiburg, Germany. ^[3] Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., White Oak Building 52/72, Room 4120, Silver Spring, MD, 20993-0002, USA. zuben.sauna@fda.hhs.gov. ^[4]

关键词 Complement C1q Fc gamma receptors Fc-fusion Immunogenicity

主题词动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);细胞系, 肿瘤(Cell Line, Tumor);补体C1q(Complement C1q);药物过敏(Drug Hypersensitivity);组织相容性抗原Ⅰ类(Histocompatibility Antigens Class I);人类(Humans);免疫球蛋白Fc片段(Immunoglobulin Fc Fragments);小鼠(Mice);蛋白质结合(Protein Binding);受体, Fc(Receptors, Fc);受体, IgG(Receptors, IgG);信号传导(Signal Transduction)

DOI 10.1208/s12248-019-0336-8

PMID 31062128

发布时间 2020-03-23

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The AAPS journal

The AAPS journal

2019年21卷4期

62页

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