Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk.-论文-万方医学网

作者： William W,Greenwald ^[1] ; Joshua,Chiou ^[2] ; Jian,Yan ^[3] ; Yunjiang,Qiu ^[4] ; Ning,Dai ^[1] ; Allen,Wang ^[3] ; Naoki,Nariai ^[5] ; Anthony,Aylward ^[6] ; Jee Yun,Han ^[7] ; Nikita,Kadakia ^[6] ; Laura,Regue ^[1] ; Mei-Lin,Okino ^[7] ; Frauke,Drees ^[6] ; Dana,Kramer ^[5] ; Nicholas,Vinckier ^[6] ; Liliana,Minichiello ^[6] ; David,Gorkin ^[8] ; Joseph,Avruch ^[6] ; Kelly A,Frazer ^[8] ; Maike,Sander ^[9] ; Bing,Ren ^[7] ; Kyle J,Gaulton ^[5]

作者单位： Bioinformatics and Systems Biology Graduate Program, UC San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA. ^[1] Biomedical Sciences Graduate Program, UC San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA. ^[2] Ludwig Institute for Cancer Research, 9500 Gilman Drive, La Jolla, CA, 92093, USA. ^[3] Department of Medical Biochemistry and Biophysics, Division of Functional Genomics and Systems Biology, Karolinska Institutet, SE-171 77, Stockholm, Sweden. ^[4] Department of Molecular and Cellular Biology, Harvard University, 52 Oxford Street, Cambridge, MA, 02138, USA. ^[5] Department of Pediatrics, UC San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA. ^[6] Center for Epigenomics, UC San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA. ^[7] European Molecular Biology Laboratory, Mouse Biology Unit, Via Ramarini 32, 00015, Monterotondo, Italy. ^[8] Department of Pharmacology, University of Oxford, OX1 3QT, Oxford, UK. ^[9] Department of Cellular and Molecular Medicine, UC San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA. ^[10] Department of Pediatrics, UC San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA. kgaulton@ucsd.edu. ^[11]

主题词成年人(Adult);动物(Animals);细胞核(Cell Nucleus);染色质(Chromatin);染色质组装和分解(Chromatin Assembly and Disassembly);糖尿病, 2型(Diabetes Mellitus, Type 2);增强子元件, 遗传学(Enhancer Elements, Genetic);女(雌)性(Female);基因表达谱(Gene Expression Profiling);基因调控网络(Gene Regulatory Networks);疾病遗传易感性(Genetic Predisposition to Disease);葡萄糖(Glucose);人类(Humans);胰岛素(Insulin);胰岛(Islets of Langerhans);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);中年人(Middle Aged);分子构象(Molecular Conformation);数量性状基因座位(Quantitative Trait Loci);RNA结合蛋白质类(RNA-Binding Proteins)

DOI 10.1038/s41467-019-09975-4

PMID 31064983

发布时间 2023-06-17

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Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk.

Nature communications

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Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk.

Nature communications

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Nature communications

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