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首页> Scientific reports> Human gut derived-organoids provide model to study gluten response and effects of microbiota-derived molecules in celiac disease.

Human gut derived-organoids provide model to study gluten response and effects of microbiota-derived molecules in celiac disease.

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作者： Rachel,Freire ^[1] ; Laura,Ingano ^[2] ; Gloria,Serena ^[1] ; Murat,Cetinbas ^[1] ; Anthony,Anselmo ^[2] ; Anna,Sapone ^[2] ; Ruslan I,Sadreyev ^[3] ; Alessio,Fasano ^[2] ; Stefania,Senger ^[3]

作者单位： Mucosal Immunology and Biology Research Center and Center for Celiac Research and Treatment, Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA. ^[1] Harvard Medical School, Boston, MA, USA. ^[2] Department of Molecular Biology, Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA. ^[3] PatientsLikeMe, Inc., Cambridge, MA, USA. ^[4] Translational Research and Early Clinical (TREC), GI, Takeda Pharmaceuticals International Co., Boston, MA, USA. ^[5] European Biomedical Research Institute of Salerno (EBRIS), Salerno, Italy. ^[6] Mucosal Immunology and Biology Research Center and Center for Celiac Research and Treatment, Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA. ssenger@mgh.harvard.edu. ^[7] Harvard Medical School, Boston, MA, USA. ssenger@mgh.harvard.edu. ^[8]

主题词成年人(Adult);老年人(Aged);乳糜泻(Celiac Disease);细胞增殖(Cell Proliferation);细胞因子类(Cytokines);十二指肠(Duodenum);基因表达(Gene Expression);麦醇溶蛋白(Gliadin);谷蛋白类(Glutens);人类(Humans);肠黏膜(Intestinal Mucosa);中年人(Middle Aged);类器官(Organoids);结果可重复性(Reproducibility of Results);干细胞(Stem Cells)

DOI 10.1038/s41598-019-43426-w

PMID 31065051

发布时间 2021-01-09

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Scientific reports

Scientific reports

2019年9卷1期

7029页

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