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How RB1CC1/FIP200 claws its way to autophagic engulfment of SQSTM1/p62-ubiquitin condensates.

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第一作者： Eleonora,Turco

第一单位： a Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories (MFPL) , University of Vienna, Vienna BioCenter , Vienna , Austria.

作者： Eleonora,Turco ^[1] ; Marie,Witt ^[2] ; Christine,Abert ^[1] ; Tobias,Bock-Bierbaum ^[3] ; Ming-Yuan,Su ^[4] ; Riccardo,Trapannone ^[1] ; Martin,Sztacho ^[1] ; Alberto,Danieli ^[1] ; Xiaoshan,Shi ^[5] ; Gabriele,Zaffagnini ^[1] ; Annamaria,Gamper ^[1] ; Martina,Schuschnig ^[1] ; Dorotea,Fracchiolla ^[1] ; Daniel,Bernklau ^[1] ; Julia,Romanov ^[1] ; Markus,Hartl ^[1] ; James H,Hurley ^[4] ; Oliver,Daumke ^[2] ; Sascha,Martens ^[1]

作者单位： a Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories (MFPL) , University of Vienna, Vienna BioCenter , Vienna , Austria. ^[1] b Crystallography , Max-Delbrück-Center for Molecular Medicine , Berlin , Germany.;c Institute of Chemistry and Biochemistry , Freie Universität Berlin , Berlin , Germany. ^[2] b Crystallography , Max-Delbrück-Center for Molecular Medicine , Berlin , Germany. ^[3] d Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences , University of California , Berkeley , CA , USA.;e Molecular Biophysics and Integrated Bioimaging Division , Lawrence Berkeley National Laboratory , Berkeley , CA , USA. ^[4] d Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences , University of California , Berkeley , CA , USA. ^[5]

关键词 Aggrephagy Atg8 ULK1 autophagosome autophagy cargo receptor phase separation protein quality control

医学主题词动物(Animals);自噬(Autophagy);人类(Humans);模型, 生物学(Models, Biological);蛋白质结合(Protein Binding);泛素(Ubiquitin)

DOI 10.1080/15548627.2019.1615306

PMID 31066340

发布时间 2025-05-30

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