Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1.-论文-万方医学网

第一作者： Hanadie,Yousef

第一单位： Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.

作者： Hanadie,Yousef ^[1] ; Cathrin J,Czupalla ^[2] ; Davis,Lee ^[2] ; Michelle B,Chen ^[3] ; Ashley N,Burke ^[4] ; Kristy A,Zera ^[1] ; Judith,Zandstra ^[2] ; Elisabeth,Berber ^[5] ; Benoit,Lehallier ^[1] ; Vidhu,Mathur ^[2] ; Ramesh V,Nair ^[1] ; Liana N,Bonanno ^[1] ; Andrew C,Yang ^[2] ; Todd,Peterson ^[1] ; Husein,Hadeiba ^[2] ; Taylor,Merkel ^[1] ; Jakob,Körbelin ^[2] ; Markus,Schwaninger ^[1] ; Marion S,Buckwalter ^[2] ; Stephen R,Quake ^[6] ; Eugene C,Butcher ^[1] ; Tony,Wyss-Coray ^[2]

作者单位： Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA. ^[1] VA Palo Alto Health Care System, Palo Alto, CA, USA. ^[2] Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. ^[3] Palo Alto Veterans Institute for Research, Palo Alto, CA, USA. ^[4] Departments of Bioengineering and Applied Physics, Stanford University, Stanford, CA, USA. ^[5] Stanford Center for Genomics and Personalized Medicine, Stanford University School of Medicine, Stanford, CA, USA. ^[6] Section of Pneumology, Department of Oncology, Hematology and Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ^[7] Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lubeck, Lubeck, Germany. ^[8] Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA. ^[9] Chan Zuckerberg Biohub, Stanford, CA, USA. ^[10] Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA. twc@stanford.edu. ^[11] VA Palo Alto Health Care System, Palo Alto, CA, USA. twc@stanford.edu. ^[12] Palo Alto Veterans Institute for Research, Palo Alto, CA, USA. twc@stanford.edu. ^[13] Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA. twc@stanford.edu. ^[14]

主题词青少年(Adolescent);成年人(Adult);老年人(Aged);衰老(Aging);动物(Animals);血脑屏障(Blood-Brain Barrier);脑(Brain);细胞, 培养的(Cells, Cultured);内皮细胞(Endothelial Cells);女(雌)性(Female);基因缺失(Gene Deletion);海马(Hippocampus);人类(Humans);炎症介导素类(Inflammation Mediators);男(雄)性(Male);小鼠(Mice);小鼠, 近交NOD(Mice, Inbred NOD);小鼠, 基因敲除(Mice, Knockout);小鼠, SCID(Mice, SCID);小神经胶质细胞(Microglia);神经干细胞(Neural Stem Cells);血管细胞黏附分子1(Vascular Cell Adhesion Molecule-1);青年人(Young Adult)

DOI 10.1038/s41591-019-0440-4

PMID 31086348

发布时间 2022-04-17

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Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1.

Nature medicine

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Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1.

Nature medicine

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Nature medicine

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