Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer.

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作者： Maria T,Grinde ^[1] ; Bylgja,Hilmarsdottir ^[2] ; Hanna Maja,Tunset ^[3] ; Ida Marie,Henriksen ^[4] ; Jana,Kim ^[5] ; Mads H,Haugen ^[4] ; Morten Beck,Rye ^[6] ; Gunhild M,Mælandsmo ^[2] ; Siver A,Moestue ^[7]

作者单位： Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), 7489, Trondheim, Norway. maria.t.grinde@ntnu.no. ^[1] Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway. ^[2] Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. ^[3] Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), 7489, Trondheim, Norway. ^[4] Department of Physics, NTNU, Trondheim, Norway. ^[5] Department of Radiology and Nuclear Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. ^[6] Department of Cancer Research and Molecular Medicine, NTNU, Trondheim, Norway. ^[7] Clinic of Surgery, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway. ^[8] Institute of Medical Biology, Faculty of Health Sciences, University of Tromsø - The Arctic University of Norway, Tromsø, Norway. ^[9] Department of Clinical and Molecular Medicine, NTNU, Trondheim, Norway. ^[10] Department of Pharmacy, Nord Universitet, Namsos, Norway. ^[11]

关键词 13C MRS Aldehyde dehydrogenase 18 family member A1 (ALDH18A1)CB-839 Cancer treatment Gene expression analysis Glutaminase Glutaminase inhibitor High-resolution magic angle spinning MR spectroscopy (HR MAS MRS)Immunohistochemistry Patient-derived xenograft (PDX)