Reduced Neoantigen Expression Revealed by Longitudinal Multiomics as a Possible Immune Evasion Mechanism in Glioma.-论文-万方医学网

作者： Takahide,Nejo ^[1] ; Hirokazu,Matsushita ^[2] ; Takahiro,Karasaki ^[2] ; Masashi,Nomura ^[3] ; Kuniaki,Saito ^[2] ; Shota,Tanaka ^[3] ; Shunsaku,Takayanagi ^[1] ; Taijun,Hana ^[4] ; Satoshi,Takahashi ^[5] ; Yosuke,Kitagawa ^[1] ; Tsukasa,Koike ^[1] ; Yukari,Kobayashi ^[1] ; Genta,Nagae ^[4] ; Shogo,Yamamoto ^[1] ; Hiroki,Ueda ^[1] ; Kenji,Tatsuno ^[1] ; Yoshitaka,Narita ^[2] ; Motoo,Nagane ^[4] ; Keisuke,Ueki ^[4] ; Ryo,Nishikawa ^[4] ; Hiroyuki,Aburatani ^[4] ; Akitake,Mukasa ^[6] ; Nobuhito,Saito ^[5] ; Kazuhiro,Kakimi ^[7]

作者单位： Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. ^[1] Department of Immunotherapeutics, The University of Tokyo Hospital, Tokyo, Japan. ^[2] Cancer Immunology Data Multi-level Integration Unit, Medical Science Innovation Hub Program, RIKEN, Tokyo, Japan. ^[3] Genome Science Division, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Tokyo, Japan. ^[4] Department of Neurosurgery, Kyorin University Faculty of Medicine, Tokyo, Japan. ^[5] Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan. ^[6] Department of Neurosurgery, Dokkyo Medical University, Tochigi, Japan. ^[7] Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Saitama, Japan. ^[8] Genome Science Division, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Tokyo, Japan. kakimi@m.u-tokyo.ac.jp mukasa@kumamoto-u.ac.jp haburata-tky@umin.ac.jp. ^[9] Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. kakimi@m.u-tokyo.ac.jp mukasa@kumamoto-u.ac.jp haburata-tky@umin.ac.jp. ^[10] Department of Immunotherapeutics, The University of Tokyo Hospital, Tokyo, Japan. kakimi@m.u-tokyo.ac.jp mukasa@kumamoto-u.ac.jp haburata-tky@umin.ac.jp. ^[11]

主题词成年人(Adult);老年人(Aged);抗原, 肿瘤(Antigens, Neoplasm);脑肿瘤(Brain Neoplasms);女(雌)性(Female);随访研究(Follow-Up Studies);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);神经胶质瘤(Glioma);高通量核苷酸序列分析(High-Throughput Nucleotide Sequencing);人类(Humans);免疫逃避(Immune Evasion);纵向研究(Longitudinal Studies);淋巴细胞, 肿瘤浸润(Lymphocytes, Tumor-Infiltrating);男(雄)性(Male);中年人(Middle Aged);突变(Mutation);肿瘤复发, 局部(Neoplasm Recurrence, Local);预后(Prognosis);回顾性研究(Retrospective Studies);存活率(Survival Rate);青年人(Young Adult)

DOI 10.1158/2326-6066.CIR-18-0599

PMID 31088845

发布时间 2020-09-09

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Reduced Neoantigen Expression Revealed by Longitudinal Multiomics as a Possible Immune Evasion Mechanism in Glioma.

Cancer immunology research

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Cancer immunology research

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Reduced Neoantigen Expression Revealed by Longitudinal Multiomics as a Possible Immune Evasion Mechanism in Glioma.

Cancer immunology research

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Cancer immunology research

相关期刊

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