Targeting Hypoxia-Induced Carbonic Anhydrase IX Enhances Immune-Checkpoint Blockade Locally and Systemically.-论文-万方医学网

作者： Shawn C,Chafe ^[1] ; Paul C,McDonald ^[1] ; Saeed,Saberi ^[2] ; Oksana,Nemirovsky ^[1] ; Geetha,Venkateswaran ^[1] ; Samantha,Burugu ^[3] ; Dongxia,Gao ^[3] ; Alberto,Delaidelli ^[2] ; Alastair H,Kyle ^[1] ; Jennifer H E,Baker ^[1] ; Jordan A,Gillespie ^[1] ; Ali,Bashashati ^[4] ; Andrew I,Minchinton ^[1] ; Youwen,Zhou ^[5] ; Sohrab P,Shah ^[4] ; Shoukat,Dedhar ^[6]

作者单位： Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, British Columbia, Canada. ^[1] Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, British Columbia, Canada. ^[2] Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, British Columbia, Canada. ^[3] Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada. ^[4] Department of Dermatology and Skin Science, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. ^[5] Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, British Columbia, Canada. sdedhar@bccrc.ca. ^[6] Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada. ^[7]

主题词动物(Animals);细胞凋亡(Apoptosis);乳腺肿瘤(Breast Neoplasms);碳酸酐酶类(Carbonic Anhydrases);细胞增殖(Cell Proliferation);药物疗法, 联合(Drug Therapy, Combination);酶诱导(Enzyme Induction);女(雌)性(Female);基因表达调控, 酶学(Gene Expression Regulation, Enzymologic);人类(Humans);肺肿瘤(Lung Neoplasms);黑色素瘤(Melanoma);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);苯脲化合物(Phenylurea Compounds);预后(Prognosis);磺胺类(Sulfonamides);存活率(Survival Rate);肿瘤细胞, 培养的(Tumor Cells, Cultured);肿瘤微环境(Tumor Microenvironment)

DOI 10.1158/2326-6066.CIR-18-0657

PMID 31088846

发布时间 2020-09-09

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Targeting Hypoxia-Induced Carbonic Anhydrase IX Enhances Immune-Checkpoint Blockade Locally and Systemically.

Cancer immunology research

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Cancer immunology research

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Targeting Hypoxia-Induced Carbonic Anhydrase IX Enhances Immune-Checkpoint Blockade Locally and Systemically.

Cancer immunology research

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Cancer immunology research

相关期刊

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