换一批The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for <i>GRIA2</i> mRNA processing.
第一作者：
Maeve,Tischbein
第一单位：
From the Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts 01605.
作者：
关键词
RNA transportamyotrophic lateral sclerosis (ALS) (Lou Gehrig disease)excitatory neurotransmissionexcitotoxicityfused in sarcoma/translocated in liposarcoma (FUS/TLS)glutamateglutamate ionotropic receptor AMPA type subunit 2 (Gria2)glutamate receptor 2 (GluA2)neurodegenerationnucleocytoplasmic transport
主题词
主动转运, 细胞核(Active Transport, Cell Nucleus);肌萎缩侧索硬化(Amyotrophic Lateral Sclerosis);钙(Calcium);细胞核(Cell Nucleus);细胞质(Cytoplasm);额颞叶痴呆(Frontotemporal Dementia);谷氨酸(Glutamic Acid);人类(Humans);突变(Mutation);神经元(Neurons);RNA加工, 转录后(RNA Processing, Post-Transcriptional);RNA, 信使(RNA, Messenger);RNA结合蛋白质FUS(RNA-Binding Protein FUS);受体, AMPA(Receptors, AMPA);应激, 生理学(Stress, Physiological)
DOI
10.1074/jbc.RA118.005933
PMID
31092554
发布时间
2021-02-05
- 浏览3
The Journal of biological chemistry
10194-10210页
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