Functional specialization of UDP-glycosyltransferase 73P12 in licorice to produce a sweet triterpenoid saponin, glycyrrhizin.

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作者： Yuhta,Nomura ^[1] ; Hikaru,Seki ^[1] ; Tomonori,Suzuki ^[2] ; Kiyoshi,Ohyama ^[1] ; Masaharu,Mizutani ^[2] ; Tomomi,Kaku ^[3] ; Keita,Tamura ^[4] ; Eiichiro,Ono ^[1] ; Manabu,Horikawa ^[1] ; Hiroshi,Sudo ^[5] ; Hiroaki,Hayashi ^[6] ; Kazuki,Saito ^[7] ; Toshiya,Muranaka ^[8]

作者单位： Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan. ^[1] RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan. ^[2] Department of Chemistry and Materials Science, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo, 152-8551, Japan. ^[3] Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe, Hyogo, 657-8501, Japan. ^[4] Suntory Global Innovation Center Ltd, Research Institute, 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto, 619-0284, Japan. ^[5] Suntory Foundation for Life Sciences, Bioorganic Research Institute, 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto, 619-0284, Japan. ^[6] Tokiwa Phytochemical Co., Ltd, 158 Kinoko, Sakura, Chiba, 285-0801, Japan. ^[7] Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan. ^[8] School of Pharmacy, Iwate Medical University, 2-1-1 Nishitokuta, Yahaba, Iwate, 028-3694, Japan. ^[9]

关键词 Glycyrrhiza uralensis UDP-glucuronic acid UDP-glycosyltransferase divergent evolution functional specialization glycyrrhizin licorice natural variant triterpenoid saponin