R-spondin 2-LGR4 system regulates growth, migration and invasion, epithelial-mesenchymal transition and stem-like properties of tongue squamous cell carcinoma via Wnt/β-catenin signaling.

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作者： Liping,Zhang ^[1] ; Yan,Song ^[2] ; Zihang,Ling ^[1] ; Yuanyuan,Li ^[1] ; Xianyue,Ren ^[1] ; Jing,Yang ^[1] ; Zhi,Wang ^[1] ; Juan,Xia ^[1] ; Weizhen,Zhang ^[3] ; Bin,Cheng ^[4]

作者单位： Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510060, China; Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510080, China. ^[1] First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. ^[2] School of Basic Medical Science, Peking University, Beijing 100191, China. Electronic address: weizhenzhang@bjmu.edu.cn. ^[3] Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510060, China; Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: chengbin@mail.sysu.edu.cn. ^[4]

关键词 Epithelial-Mesenchymal transition Proliferation R-spodin2-LGR4 Stem-like properties Tongue squamous cell carcinoma Wnt/β-catenin signaling

主题词成年人(Adult);老年人(Aged);动物(Animals);癌, 鳞状细胞(Carcinoma, Squamous Cell);细胞系, 肿瘤(Cell Line, Tumor);疾病模型, 动物(Disease Models, Animal);上皮-间质转化(Epithelial-Mesenchymal Transition);女(雌)性(Female);人类(Humans);胞间信号肽类和蛋白质类(Intercellular Signaling Peptides and Proteins);男(雄)性(Male);小鼠(Mice);中年人(Middle Aged);肿瘤转移(Neoplasm Metastasis);肿瘤分期(Neoplasm Staging);肿瘤干细胞(Neoplastic Stem Cells);比例危险度模型(Proportional Hazards Models);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);舌肿瘤(Tongue Neoplasms)

DOI 10.1016/j.ebiom.2019.03.076

PMID 31097406

发布时间 2021-01-17

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EBioMedicine

2019年44卷

275-288页

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R-spondin 2-LGR4 system regulates growth, migration and invasion, epithelial-mesenchymal transition and stem-like properties of tongue squamous cell carcinoma via Wnt/β-catenin signaling.

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R-spondin 2-LGR4 system regulates growth, migration and invasion, epithelial-mesenchymal transition and stem-like properties of tongue squamous cell carcinoma via Wnt/β-catenin signaling.

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