Rational design, synthesis and biological evaluation of ubiquinone derivatives as IDO1 inhibitors.

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作者： Yuyang,Ding ^[1] ; Fei,Tang ^[2] ; Xiaoqian,Xue ^[3] ; Jinfeng,Luo ^[2] ; Muzammal,Hussain ^[1] ; Yanhui,Huang ^[2] ; Zhen,Wang ^[4] ; Hao,Jiang ^[5] ; Zhengchao,Tu ^[6] ; Jiancun,Zhang ^[7]

作者单位： State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, Guangzhou 510530, China; University of Chinese Academy of Sciences, Beijing 100049, China. ^[1] State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, Guangzhou 510530, China. ^[2] Huizhou University, Huizhou 516007, China. ^[3] College of Pharmacy, Jinan University, Guangzhou 510632, China. ^[4] State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, Guangzhou 510530, China. Electronic address: jiang_hao@gibh.ac.cn. ^[5] State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, Guangzhou 510530, China; College of Pharmacy, Jinan University, Guangzhou 510632, China. Electronic address: tu_zhengchao@gibh.ac.cn. ^[6] State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, Guangzhou 510530, China. Electronic address: zhang_jiancun@gibh.ac.cn. ^[7]

关键词 Docking Halogen bonding Indoleamine 2,3-dioxygenase 1 Inhibitor Ubiquinone derivatives