Protective Effects of Caffeic Acid Phenethyl Ester (CAPE) and Novel Cape Analogue as Inducers of Heme Oxygenase-1 in Streptozotocin-Induced Type 1 Diabetic Rats.

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作者： Valeria,Sorrenti ^[1] ; Marco,Raffaele ^[2] ; Luca,Vanella ^[3] ; Rosaria,Acquaviva ^[4] ; Loredana,Salerno ^[5] ; Valeria,Pittalà ^[6] ; Sebastiano,Intagliata ^[7] ; Claudia,Di Giacomo ^[8]

作者单位： Department of Drug Science, Biochemistry Section, University of Catania, 95125 Catania, Italy. sorrenti@unict.it. ^[1] Department of Drug Science, Biochemistry Section, University of Catania, 95125 Catania, Italy. marco.raffaele@hotmail.com. ^[2] Department of Drug Science, Biochemistry Section, University of Catania, 95125 Catania, Italy. lvanella@unict.it. ^[3] Department of Drug Science, Biochemistry Section, University of Catania, 95125 Catania, Italy. racquavi@unict.it. ^[4] Department of Drug Science, Pharmaceutical Chemistry Section, University of Catania, 95125 Catania, Italy. lsalerno@unict.it. ^[5] Department of Drug Science, Pharmaceutical Chemistry Section, University of Catania, 95125 Catania, Italy. vpittala@unict.it. ^[6] Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA. s.intagliata@cop.ufl.edu. ^[7] Department of Drug Science, Biochemistry Section, University of Catania, 95125 Catania, Italy. cdigiaco@unict.it. ^[8]

关键词 Caffeic acid phenethyl ester (CAPE)Dimethylarginine dimethylaminohydrolase-1 (DDAH-1)Gamma-Glutamyl-Cysteine Ligase (GGCL)Heme oxygenase-1 (HO-1) inducers Inducible nitric oxide synthase (iNOS)Pancreatic oxidative damage Reactive oxygen species (ROS)Type 1 diabetes mellitus (T1D)