Cerebellar Neurodegeneration and Neuronal Circuit Remodeling in Golgi pH Regulator-Deficient Mice.

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第一作者： Yu-Shin,Sou

第一单位： Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, Bunkyo, Tokyo 113-8421, Japan ysodaka@juntendo.ac.jp mkoike@juntendo.ac.jp.

作者： Yu-Shin,Sou ^[1] ; Soichiro,Kakuta ^[2] ; Yuji,Kamikubo ^[3] ; Kazue,Niisato ^[4] ; Takashi,Sakurai ^[4] ; Laxmi Kumar,Parajuli ^[4] ; Isei,Tanida ^[5] ; Hiromitsu,Saito ^[5] ; Noboru,Suzuki ^[6] ; Kenji,Sakimura ^[6] ; Yusuke,Maeda ^[7] ; Taroh,Kinoshita ^[8] ; Yasuo,Uchiyama ^[8] ; Masato,Koike ^[3]

作者单位： Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, Bunkyo, Tokyo 113-8421, Japan ysodaka@juntendo.ac.jp mkoike@juntendo.ac.jp. ^[1] Laboratory of Morphology and Image Analysis, Research Support Center, Juntendo University Graduate School of Medicine, Bunkyo, Tokyo 113-8421, Japan. ^[2] Department of Cellular and Molecular Neuropathology, Juntendo University Graduate School of Medicine, Bunkyo, Tokyo 113-8421, Japan. ^[3] Department of Pharmacology, Juntendo University Graduate School of Medicine, Bunkyo, Tokyo 113-8421, Japan. ^[4] Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, Bunkyo, Tokyo 113-8421, Japan. ^[5] Functional Genomics Institute, Life Science Research Center, Mie University, Tsu, Mie 514-8507, Japan. ^[6] Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata 951-8585, Japan. ^[7] Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan. ^[8] Advanced Research Institute for Health Science, Juntendo University, Bunkyo, Tokyo 113-8421, Japan. ^[9]

关键词 Golgi apparatus Golgi fragmentation Golgi pH regulator Purkinje cell cerebellar circuit neurodegeneration

主题词动物(Animals);小脑共济失调(Cerebellar Ataxia);小脑(Cerebellum);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);高尔基体(Golgi Apparatus);氢离子浓度(Hydrogen-Ion Concentration);男(雄)性(Male);小鼠, 基因敲除(Mice, Knockout);神经通路(Neural Pathways);神经元可塑性(Neuronal Plasticity);神经元(Neurons);浦肯野细胞(Purkinje Cells);受体, G-蛋白偶联(Receptors, G-Protein-Coupled)

DOI 10.1523/ENEURO.0427-18.2019

PMID 31118204

发布时间 2020-03-30

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