Inhibitory Effects of the Two Novel TSPO Ligands 2-Cl-MGV-1 and MGV-1 on LPS-induced Microglial Activation.

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作者： Sheelu,Monga ^[1] ; Rafi,Nagler ^[2] ; Rula,Amara ^[3] ; Abraham,Weizman ^[4] ; Moshe,Gavish ^[5]

作者单位： Ruth and Bruce Rappaport Faculty of Medicine, Technion- Israel Institute of Technology, Haifa 31096, Israel. sheelumonga@hotmail.com. ^[1] Ruth and Bruce Rappaport Faculty of Medicine, Technion- Israel Institute of Technology, Haifa 31096, Israel. rafi.nagler@gmail.com. ^[2] Ruth and Bruce Rappaport Faculty of Medicine, Technion- Israel Institute of Technology, Haifa 31096, Israel. rula_amara@yahoo.com. ^[3] Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel. weizmana@gmail.com. ^[4] Research Unit, Geha Mental Health Center and Felsenstein Medical Research Center, Petah Tikva 4910002, Israel. weizmana@gmail.com. ^[5] Ruth and Bruce Rappaport Faculty of Medicine, Technion- Israel Institute of Technology, Haifa 31096, Israel. mgavish@technion.ac.il. ^[6]

关键词 2-Cl-MGV-1 BV-2 cell line MGV-1 NF-κB cytokines microglial activation neuroinflammation translocator protein (TSPO)

主题词动物(Animals);氨甲酸酯类(Carbamates);细胞系(Cell Line);细胞因子类(Cytokines);炎症(Inflammation);配体(Ligands);脂多糖类(Lipopolysaccharides);小神经胶质细胞(Microglia);喹唑啉类(Quinazolines);活性氧(Reactive Oxygen Species);受体, GABA(Receptors, GABA);转录因子RelA(Transcription Factor RelA)

DOI 10.3390/cells8050486

PMID 31121852

发布时间 2021-02-18

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Cells

2019年8卷5期

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Inhibitory Effects of the Two Novel TSPO Ligands 2-Cl-MGV-1 and MGV-1 on LPS-induced Microglial Activation.

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Inhibitory Effects of the Two Novel TSPO Ligands 2-Cl-MGV-1 and MGV-1 on LPS-induced Microglial Activation.

Cells

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