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Building and Applying Quantitative Adverse Outcome Pathway Models for Chemical Hazard and Risk Assessment.

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第一作者： Edward J,Perkins

第一单位： US Army Engineer Research and Development Center, Vicksburg, Mississippi, USA.

作者： Edward J,Perkins ^[1] ; Roman,Ashauer ^[2] ; Lyle,Burgoon ^[1] ; Rory,Conolly ^[3] ; Brigitte,Landesmann ^[4] ; Cameron,Mackay ^[5] ; Cheryl A,Murphy ^[6] ; Nathan,Pollesch ^[7] ; James R,Wheeler ^[8] ; Anze,Zupanic ^[9] ; Stefan,Scholz ^[10]

作者单位： US Army Engineer Research and Development Center, Vicksburg, Mississippi, USA. ^[1] Environment Department, University of York, Heslington, York, UK.;Toxicodynamics, York, UK. ^[2] Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA. ^[3] Joint Research Centre, Ispra, Italy. ^[4] Unilever Safety and Environmental Assurance Centre, Sharnbrook, Bedford, UK. ^[5] Department of Fisheries and Wildlife, Michigan State University, East Lansing, Michigan, USA. ^[6] Mid-Continent Ecology Division, National Health and Environmental Effects Laboratory, Office of Research and Development, US Environmental Protection Agency, Duluth, Minnesota, USA. ^[7] Dow AgroSciences, Abingdon, Oxfordshire, UK. ^[8] Department of Environmental Toxicology, Swiss Federal Institute for Aquatic Science and Technology, Dübendorf, Switzerland. ^[9] Department of Bioanalytical Ecotoxicology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany. ^[10]

关键词 Alternatives to animal testing Predictive toxicology Prioritization of chemicals Quantitative adverse outcome pathways Species extrapolation Toxicokinetic/toxicodynamic modeling