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Determination of benzonatate and its metabolite in human plasma by HPLC-MS/MS: A preliminary pharmacokinetic study in healthy Chinese volunteers after oral administration of benzonatate soft capsule.

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第一作者： Jiayu,Man

第一单位： Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, 210009, China; Nanjing Clinical Tech. Laboratories Inc., Nanjing, 211100, China.

作者： Jiayu,Man ^[1] ; Feifei,Jiao ^[2] ; Yiya,Wang ^[2] ; Yueqing,Gu ^[3] ; Li,Ding ^[4] ; Chang,Shu ^[5]

作者单位： Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, 210009, China; Nanjing Clinical Tech. Laboratories Inc., Nanjing, 211100, China. ^[1] Nanjing Clinical Tech. Laboratories Inc., Nanjing, 211100, China. ^[2] Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, 210009, China. ^[3] Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, 210009, China; Nanjing Clinical Tech. Laboratories Inc., Nanjing, 211100, China. Electronic address: dingli@cpu.edu.cn. ^[4] Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: shuchang@cpu.edu.cn. ^[5]

关键词 4-(Butylamino)benzoic acid Benzonatate HPLC–MS/MS Metabolite Pharmacokinetics Polymer