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Epigenetic Control of Mitochondrial Fission Enables Self-Renewal of Stem-like Tumor Cells in Human Prostate Cancer.

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第一作者： Gianluca,Civenni

第一单位： Institute of Oncology Research (IOR), Università della Svizzera Italiana (USI), Bellinzona 6500, Switzerland.

作者： Gianluca,Civenni ^[1] ; Roberto,Bosotti ^[1] ; Andrea,Timpanaro ^[1] ; Ramiro,Vàzquez ^[1] ; Jessica,Merulla ^[1] ; Shusil,Pandit ^[1] ; Simona,Rossi ^[1] ; Domenico,Albino ^[1] ; Sara,Allegrini ^[1] ; Abhishek,Mitra ^[1] ; Sarah N,Mapelli ^[2] ; Luca,Vierling ^[1] ; Martina,Giurdanella ^[1] ; Martina,Marchetti ^[1] ; Alyssa,Paganoni ^[1] ; Andrea,Rinaldi ^[1] ; Marco,Losa ^[1] ; Enrica,Mira-Catò ^[1] ; Rocco,D'Antuono ^[3] ; Diego,Morone ^[3] ; Keyvan,Rezai ^[4] ; Gioacchino,D'Ambrosio ^[5] ; L'Houcine,Ouafik ^[6] ; Sarah,Mackenzie ^[7] ; Maria E,Riveiro ^[7] ; Esteban,Cvitkovic ^[8] ; Giuseppina M,Carbone ^[1] ; Carlo V,Catapano ^[9]

作者单位： Institute of Oncology Research (IOR), Università della Svizzera Italiana (USI), Bellinzona 6500, Switzerland. ^[1] Institute of Oncology Research (IOR), Università della Svizzera Italiana (USI), Bellinzona 6500, Switzerland; Institute of Computational Science, Università della Svizzera Italiana (USI), Lugano 6900, Switzerland; Swiss Institute of Bioinformatics (SIB), Lausanne 1015, Switzerland. ^[2] Institute for Research in Biomedicine (IRB), Università della Svizzera Italiana (USI), Bellinzona 6500, Switzerland. ^[3] Institute Curie-Hospital René Huguenin, Saint Cloud 92210, France. ^[4] IRCCS Multimedica, Milan 20122, Italy. ^[5] Aix-Marseille Université, Inserm, Marseille 13007, France. ^[6] Oncology Therapeutic Development (OTD), Clichy 92110, France. ^[7] Oncology Therapeutic Development (OTD), Clichy 92110, France; Oncoethix GmbH, Merck Sharp and Dohme Corp., Lucerne 6006, Switzerland. ^[8] Institute of Oncology Research (IOR), Università della Svizzera Italiana (USI), Bellinzona 6500, Switzerland; Swiss Institute of Bioinformatics (SIB), Lausanne 1015, Switzerland; Department of Oncology, Faculty of Biology and Medicine, University of Lausanne, Lausanne 1005, Switzerland. Electronic address: carlo.catapano@ior.usi.ch. ^[9]

关键词 BET inhibitors BRD4 MFF OTX015/MK-8628 bromodomain and extra-terminal domain proteins cancer stem cells mitochondrial dynamics mitochondrial fission mitochondrial fission factor prostate cancer