Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids.

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第一作者： Benedetta,Artegiani

第一单位： Oncode Institute, Utrecht, the Netherlands; Hubrecht Institute, KNAW (Royal Netherlands Academy of Arts and Sciences), Utrecht, the Netherlands.

作者： Benedetta,Artegiani ^[1] ; Lisa,van Voorthuijsen ^[2] ; Rik G H,Lindeboom ^[2] ; Daniëlle,Seinstra ^[3] ; Inha,Heo ^[4] ; Pablo,Tapia ^[1] ; Carmen,López-Iglesias ^[5] ; Daniel,Postrach ^[3] ; Talya,Dayton ^[1] ; Rurika,Oka ^[6] ; Huili,Hu ^[7] ; Ruben,van Boxtel ^[6] ; Johan H,van Es ^[1] ; Johan,Offerhaus ^[8] ; Peter J,Peters ^[5] ; Jacco,van Rheenen ^[3] ; Michiel,Vermeulen ^[2] ; Hans,Clevers ^[9]

作者单位： Oncode Institute, Utrecht, the Netherlands; Hubrecht Institute, KNAW (Royal Netherlands Academy of Arts and Sciences), Utrecht, the Netherlands. ^[1] Oncode Institute, Utrecht, the Netherlands; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Science, Radboud University Nijmegen, Nijmegen, the Netherlands. ^[2] Oncode Institute, Utrecht, the Netherlands; Molecular Pathology, the Netherlands Cancer Institute, Amsterdam, the Netherlands. ^[3] Hubrecht Institute, KNAW (Royal Netherlands Academy of Arts and Sciences), Utrecht, the Netherlands. ^[4] The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, 6229ER Maastricht, the Netherlands. ^[5] The Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands. ^[6] Oncode Institute, Utrecht, the Netherlands; The Key Laboratory of Experimental Teratology, Ministry of Education and Department of Genetics, School of Basic Medical Sciences, Shandong University, 250012 Jinan, China. ^[7] Department of Pathology, UMC Utrecht, 3584CX Utrecht, the Netherlands. ^[8] Oncode Institute, Utrecht, the Netherlands; Hubrecht Institute, KNAW (Royal Netherlands Academy of Arts and Sciences), Utrecht, the Netherlands; The Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; University Medical Center Utrecht, Cancer Genomics Netherlands, 3584CX Utrecht, the Netherlands. Electronic address: h.clevers@hubrecht.eu. ^[9]

关键词 BAP1 CRISPR/Cas9 cancer cholangiocarcinoma epigenetics genome editing human organoids liver tumor modeling