Targeted Degradation of a Hypoxia-Associated Non-coding RNA Enhances the Selectivity of a Small Molecule Interacting with RNA.

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作者： Matthew G,Costales ^[1] ; Blessy,Suresh ^[1] ; Kamalakannan,Vishnu ^[1] ; Matthew D,Disney ^[2]

作者单位： Department of Chemistry, Scripps Research, Jupiter, FL 33458, USA. ^[1] Department of Chemistry, Scripps Research, Jupiter, FL 33458, USA. Electronic address: disney@scripps.edu. ^[2]

关键词 RNA chemical biology nucleic acids targeted degradation

主题词剂量效应关系, 药物(Dose-Response Relationship, Drug);人类(Humans);分子结构(Molecular Structure);RNA, 未翻译(RNA, Untranslated);小分子化合物库(Small Molecule Libraries);构效关系(Structure-Activity Relationship);肿瘤细胞, 培养的(Tumor Cells, Cultured)

DOI 10.1016/j.chembiol.2019.04.008

PMID 31130520

发布时间 2023-09-29

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Cell chemical biology

2019年26卷8期

1180-1186.e5页

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Targeted Degradation of a Hypoxia-Associated Non-coding RNA Enhances the Selectivity of a Small Molecule Interacting with RNA.

Cell chemical biology

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Targeted Degradation of a Hypoxia-Associated Non-coding RNA Enhances the Selectivity of a Small Molecule Interacting with RNA.

Cell chemical biology

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Cell chemical biology

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