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Somatic mutations and promotor methylation of the ryanodine receptor 2 is a common event in the pathogenesis of head and neck cancer.

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作者单位: Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany. [1] Molecular Mechanisms of Head and Neck Tumors, German Cancer Research Center (DKFZ), Heidelberg, Germany. [2] Oral Pathology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. [3] Division of Molecular and Translational Radiation Oncology, Heidelberg Ion Therapy Center (HIT), Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg University Hospital, and Translational Radiation Oncology, German Cancer Consortium (DKTK), National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany. [4] Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), and Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Heidelberg, Germany. [5] Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany. [6] Institute of Physiology and Pathophysiology, Division of Cardiovascular Physiology, Heidelberg University, Heidelberg, Germany. [7] Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden, Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany. [8] Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany. [9] Division of Molecular Diagnostics of Oncogenic Infections, Infection, Inflammation and Cancer Program, German Cancer Research Center (DKFZ), Heidelberg, Germany. [10] Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Ulm, Ulm, Germany. [11] Institute of Pathology, University Hospital Ulm, Ulm, Germany. [12] Department of Otorhinolaryngology, Head and Neck Surgery, University of Giessen, Giessen, Germany. [13] Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany. [14] Department of Oral and Maxillofacial Surgery, Heidelberg University Hospital, Heidelberg, Germany. [15] Institute of Pathology, Technical University Munich (TUM), and German Cancer Consortium (DKTK) partner site, Munich, Germany. [16]
DOI 10.1002/ijc.32481
PMID 31135957
发布时间 2020-01-30
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International journal of cancer

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