首页> Sleep> Epigenome-wide association analysis of daytime sleepiness in the Multi-Ethnic Study of Atherosclerosis reveals African-American-specific associations.

Epigenome-wide association analysis of daytime sleepiness in the Multi-Ethnic Study of Atherosclerosis reveals African-American-specific associations.

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第一作者： Richard,Barfield

第一单位： Department of Epidemiology, University of Washington, Seattle, WA.;Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.

作者： Richard,Barfield ^[1] ; Heming,Wang ^[2] ; Yongmei,Liu ^[3] ; Jennifer A,Brody ^[4] ; Brenton,Swenson ^[5] ; Ruitong,Li ^[6] ; Traci M,Bartz ^[5] ; Nona,Sotoodehnia ^[4] ; Yii-der I,Chen ^[7] ; Brian E,Cade ^[2] ; Han,Chen ^[8] ; Sanjay R,Patel ^[9] ; Xiaofeng,Zhu ^[10] ; Sina A,Gharib ^[11] ; W Craig,Johnson ^[12] ; Jerome I,Rotter ^[7] ; Richa,Saxena ^[13] ; Shaun,Purcell ^[14] ; Xihong,Lin ^[15] ; Susan,Redline ^[16] ; Tamar,Sofer ^[17]

作者单位： Department of Epidemiology, University of Washington, Seattle, WA.;Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA. ^[1] Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.;Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA.;Division of Sleep Medicine, Harvard Medical School, Boston, MA. ^[2] Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC. ^[3] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA. ^[4] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.;Institute for Public Health Genetics, University of Washington, Seattle, WA. ^[5] Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA.;Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA. ^[6] The Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA. ^[7] Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA.;Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.;Center for Precision Health, School of Public Health & School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX. ^[8] Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA. ^[9] Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH. ^[10] Computational Medicine Core, Center for Lung Biology, University of Washington Medicine Sleep Center, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, WA. ^[11] Department of Biostatistics, University of Washington, Seattle, WA. ^[12] Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.;Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA.;Division of Sleep Medicine, Harvard Medical School, Boston, MA.;Center for Genomic Medicine and Department of Anesthesia, Pain, and Critical Care Medicine, Massachusetts General Hospital, Boston, MA. ^[13] Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.;Department of Psychiatry, Brigham & Women's Hospital, Harvard Medical School, Boston, MA. ^[14] Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA.;Department of Statistics, Harvard University, Cambridge, MA. ^[15] Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA.;Division of Sleep Medicine, Harvard Medical School, Boston, MA.;Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA. ^[16] Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA.;Division of Sleep Medicine, Harvard Medical School, Boston, MA.;Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA. ^[17]

关键词 diversity epigenetics excessive daytime sleepiness genomics methylation race/ethnic heterogeneity sleep–wake