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Ligand-independent activation of the P2X7 receptor by Hsp90 inhibition stimulates motor neuron apoptosis.

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第一作者： Amy L,Strayer

第一单位： 1 Department of Neuroscience Weill Cornell Medical College, New York, NY10021, USA.

作者： Amy L,Strayer ^[1] ; Cassandra N,Dennys-Rivers ^[2] ; Karina C,Ricart ^[3] ; Narae,Bae ^[4] ; Joseph S,Beckman ^[5] ; Maria Clara,Franco ^[5] ; Alvaro G,Estevez ^[5]

作者单位： 1 Department of Neuroscience Weill Cornell Medical College, New York, NY10021, USA. ^[1] 2 Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32826, USA. ^[2] 3 Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. ^[3] 4 Department of Pharmacology, Weill Cornell Medical College, New York, NY10021, USA. ^[4] 5 Department of Biochemistry and Biophysics, College of Science, Oregon State University, Corvallis, OR 97331, USA. ^[5]

关键词 Fas Heat shock protein 90 P2X7 apoptosis motor neuron phosphatase and tensin homolog